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KDM1A and UCHL5
Data Source:
BioGRID
(two hybrid)
KDM1A
UCHL5
Description
lysine demethylase 1A
ubiquitin C-terminal hydrolase L5
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Protein-containing Complex
DNA Repair Complex
Proteasome Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Ino80 Complex
Molecular Function
RNA Polymerase II Transcription Factor Binding
P53 Binding
Chromatin Binding
Protein Binding
Transcription Factor Binding
Oxidoreductase Activity
Enzyme Binding
Nuclear Receptor Coactivator Activity
Demethylase Activity
Histone Demethylase Activity
Histone Demethylase Activity (H3-K4 Specific)
Histone Demethylase Activity (H3-K9 Specific)
Histone Demethylase Activity (H3-dimethyl-K4 Specific)
Telomeric DNA Binding
MRF Binding
Flavin Adenine Dinucleotide Binding
Androgen Receptor Binding
Telomeric Repeat-containing RNA Binding
Promoter-specific Chromatin Binding
RNA Binding
Thiol-dependent Ubiquitin-specific Protease Activity
Endopeptidase Inhibitor Activity
Protein Binding
Cysteine-type Peptidase Activity
Proteasome Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Alternative MRNA Splicing, Via Spliceosome
Positive Regulation Of Neuroblast Proliferation
Regulation Of Transcription By RNA Polymerase II
Protein Demethylation
Blood Coagulation
Regulation Of Double-strand Break Repair Via Homologous Recombination
Positive Regulation Of Neuron Projection Development
Cerebral Cortex Development
Negative Regulation Of Protein Binding
Histone H3-K9 Demethylation
Positive Regulation Of Histone Ubiquitination
Cellular Response To UV
Histone H3-K4 Demethylation
Positive Regulation Of Chromatin Binding
Neuron Maturation
Negative Regulation Of DNA Binding
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator
Positive Regulation Of Cell Size
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Guanine Metabolic Process
Positive Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Histone H3-K4 Methylation
Negative Regulation Of Histone H3-K9 Methylation
Muscle Cell Development
Response To Fungicide
Cellular Response To CAMP
Cellular Response To Gamma Radiation
Positive Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Cellular Protein Localization
Positive Regulation Of Neural Precursor Cell Proliferation
Positive Regulation Of Stem Cell Proliferation
DNA Repair
DNA Recombination
Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Endopeptidase Activity
Protein Deubiquitination
Protein Phosphopantetheinylation
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Smoothened Signaling Pathway
Regulation Of Proteasomal Protein Catabolic Process
Pathways
HDACs deacetylate histones
HDMs demethylate histones
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Regulation of PTEN gene transcription
Estrogen-dependent gene expression
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Potential therapeutics for SARS
Factors involved in megakaryocyte development and platelet production
Downregulation of TGF-beta receptor signaling
UCH proteinases
UCH proteinases
Drugs
Diseases
GWAS
Brain morphology (min-P) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Cortical surface area (min-P) (
32665545
)
Cortical surface area (MOSTest) (
32665545
)
Cortical thickness (min-P) (
32665545
)
Cortical thickness (MOSTest) (
32665545
)
Gamma glutamyl transferase levels (
29403010
)
Global electrical heterogeneity phenotypes (
29622589
)
Pulse pressure (
27841878
)
Subcortical volume (min-P) (
32665545
)
Subcortical volume (MOSTest) (
32665545
)
Cannabis dependence (
21668797
)
Interacting Genes
265 interacting genes:
AKAP9
ANKEF1
ANKRD23
AP1G2
AR
ARHGAP15
ARHGAP29
ASB10
ASB3
ASCC2
ATP5MF
ATP6V1B1
BAHD1
BAIAP2
BATF
BCAT1
BIRC2
BLZF1
BMP3
BRCA1
C18orf54
C4orf17
C8orf48
C8orf74
CAGE1
CARD10
CCDC121
CCDC14
CCDC172
CCDC33
CCDC74A
CCDC74B
CCDC90B
CDC23
CDC5L
CDCA4
CDCA5
CENPQ
CEP162
CEP57
CEP70
CEP76
CFAP100
COIL
CRBN
CRLF3
CSNK2A1
CSNK2A2
CTBP1
DBF4B
DNAAF4
DNAJA3
DNTTIP1
E2F1
ECI2
ELOF1
EXOC1
EXOC7
FAM161A
FAM204A
FAM9A
FIGNL1
FYCO1
FYN
GABPB2
GAS8
GATA3
GCC1
GDF9
GLYR1
GOLGA2
GOLGA6A
GPATCH2L
GSK3B
GSTCD
GTPBP2
H3-4
H3-5
H3C1
H3C14
HAUS1
HAUS3
HAUS6
HDAC1
HESX1
HOMER3
HOXA1
ID2
IFI35
IGFBP4
IK
IKBIP
IL16
IMMT
INSM1
INTS2
ISL1
ITGB3BP
ITSN2
JRK
KANSL1
KASH5
KDM5B
KIAA0408
KIFC3
KLC3
KLF3
KLHDC4
KRT15
KRT17
KRT19
KRT222
KRT31
KRT33B
KRT35
KRT38
KRT39
KRT40
KRT6A
KRT6B
KRT7
L3MBTL3
LENG8
LINC02875
LOXL4
LZTS1
MALT1
MBD3
MBD4
MCPH1
MCRS1
METTL27
MLC1
MNS1
MTA3
MTF2
MTMR9
MTO1
MYC
MYLIP
NBPF15
NBPF26
NDUFA8
NDUFS1
NECAB2
NEFL
NF2
NFE2L2
NMI
NOSTRIN
NR1H2
NR1H3
NR2C2
NR2E1
NRBF2
ODAD3
OFCC1
OIP5
OPA3
OTUB1
PBX4
PDCD5
PDE4DIP
PEX7
PFDN5
PHC2
PHF19
PHF20L1
PHF21A
PMF1
PNKP
PPARD
PPM1D
PPP1R12A
PRDM1
PRIM2
PSMC1
PSMC3
PTEN
RASSF1
RASSF2
RASSF3
RASSF8
RCOR1
RCOR3
RIOK1
RNF10
RNF168
RPRD1A
SAMD3
SEPTIN6
SERGEF
SETDB1
SF3B2
SH3GLB2
SLU7
SMAD9
SMARCD1
SMN1
SNF8
SNX15
SOCS6
SPATA22
SPATA24
SPICE1
SPRY2
SPSB1
SPZ1
SRGAP3
SSX2IP
STAT3
STX11
STX19
SUMO2
SUV39H1
TACC1
TADA3
TAL1
TDO2
TEDC2
TERF1
TEX35
TEX9
TFIP11
TLE5
TMEM266
TNFAIP1
TNNT2
TP53
TP53BP1
TP53BP2
TRAF4
TRIM39
TRIM54
TSACC
TSC1
TTC23
TTC33
UBA3
UBASH3B
UBE2I
UCHL5
UNC119
UNKL
USP28
USP7
VPS11
VPS37A
VPS37B
WASHC3
WDR83
ZBED1
ZBTB24
ZBTB39
ZCCHC17
ZFP28
ZNF280A
ZNF333
ZNF436
ZNF451
ZNF480
ZNF581
ZNF641
ZNF71
ZNF829
102 interacting genes:
ACTN4
ADRM1
ANP32B
ANP32E
ANXA1
ANXA4
ANXA7
ANXA8
ANXA8L1
APP
ARG1
ASPRV1
CALM1
CAP1
CAPZA1
CASP14
CDSN
CFL1
CSTA
DSC1
DSC3
DSP
DUSP14
E2F1
E2F2
E2F3
EEF1G
EEF2
EIF4A1
EPPK1
FLG
GSTM3
H4-16
H4C1
H4C11
H4C12
H4C13
H4C14
H4C15
H4C2
H4C3
H4C4
H4C5
H4C6
H4C8
H4C9
HAUS7
HBA1
HBA2
HBB
HSPB1
IDE
IGHG1
IVL
KDM1A
KRT12
KRT19
KRT26
KRT28
KRT73
KRT78
KRT80
LMNA
MAP3K1
NACA
NFRKB
PJA1
PKM
PKP1
PLA2G2A
PNP
POF1B
PRDX6
PSMD8
RAB7A
RBCK1
RFFL
S100A14
S100A16
S100A7
SERPINB12
SERPINB3
SERPINB5
SET
SMAD2
SMAD3
SMAD7
TCF7
TGM3
TPI1
TRIM27
TRIM46
TRIM54
TRIM55
TRIM63
TUBA4A
TXN
TXN2
UBC
USP28
YWHAZ
ZBED1
Entrez ID
23028
51377
HPRD ID
09800
10293
Ensembl ID
ENSG00000004487
ENSG00000116750
Uniprot IDs
O60341
Q9Y5K5
PDB IDs
2COM
2DW4
2EJR
2H94
2HKO
2IW5
2L3D
2UXN
2UXX
2V1D
2X0L
2XAF
2XAG
2XAH
2XAJ
2XAQ
2XAS
2Y48
2Z3Y
2Z5U
3ABT
3ABU
3ZMS
3ZMT
3ZMU
3ZMV
3ZMZ
3ZN0
3ZN1
4BAY
4CZZ
4KUM
4UV8
4UV9
4UVA
4UVB
4UVC
4UXN
4XBF
5AFW
5H6Q
5H6R
5IT3
5L3B
5L3C
5L3D
5L3E
5L3F
5L3G
5LBQ
5LGN
5LGT
5LGU
5LHG
5LHH
5LHI
5X60
5YJB
6E1F
6K3E
6KGK
6KGL
6KGM
6KGN
6KGO
6KGP
6KGQ
6KGR
6NQM
6NQU
6NR5
6S35
6TE1
6VYP
6W4K
7JJL
7JJM
7JK7
3A7S
3IHR
3RII
3RIS
3TB3
4UEL
4UEM
4UF5
4UF6
4WLP
Enriched GO Terms of Interacting Partners
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