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MMP1 and COL2A1
Data Source:
HPRD
(in vitro)
MMP1
COL2A1
Description
matrix metallopeptidase 1
collagen type II alpha 1 chain
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Matrix
Extracellular Region
Collagen Trimer
Collagen Type II Trimer
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Collagen-containing Extracellular Matrix
Molecular Function
Endopeptidase Activity
Metalloendopeptidase Activity
Serine-type Endopeptidase Activity
Peptidase Activity
Zinc Ion Binding
Extracellular Matrix Structural Constituent
Extracellular Matrix Structural Constituent Conferring Tensile Strength
MHC Class II Protein Binding
Identical Protein Binding
Proteoglycan Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Biological Process
Proteolysis
Viral Process
Cytokine-mediated Signaling Pathway
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Collagen Catabolic Process
Positive Regulation Of Protein-containing Complex Assembly
Cellular Protein Metabolic Process
Leukocyte Migration
Cellular Response To UV-A
Skeletal System Development
Cartilage Condensation
Tissue Homeostasis
Endochondral Ossification
Chondrocyte Differentiation
Heart Morphogenesis
Proteoglycan Metabolic Process
Central Nervous System Development
Visual Perception
Sensory Perception Of Sound
Regulation Of Gene Expression
Extracellular Matrix Organization
Collagen Fibril Organization
Notochord Development
Inner Ear Morphogenesis
Regulation Of Immune Response
Cartilage Development
Roof Of Mouth Development
Limb Bud Formation
Embryonic Skeletal Joint Morphogenesis
Cartilage Development Involved In Endochondral Bone Morphogenesis
Otic Vesicle Development
Cellular Response To BMP Stimulus
Anterior Head Development
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Collagen degradation
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Basigin interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Interleukin-4 and Interleukin-13 signaling
Collagen degradation
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Integrin cell surface interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
NCAM1 interactions
MET activates PTK2 signaling
Collagen chain trimerization
Drugs
Marimastat
CGS-27023
N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE
METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID
[[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER
N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE
Collagenase clostridium histolyticum
Diseases
Choriocarcinoma
Type II collagenopathies, including: Achondrogenesis II; Hypochondrogenesis; SED congenita; SMED Strudwick type; Kniest dysplasia; Spondyloperipheral dysplasia; Osteoarthritis with mild chondrodysplasia; Stickler syndrome 1; Platyspondylic skeletal dysplasia, Torrance type; Epiphyseal dysplasia, multiple, with myopia and deafness; Czech dysplasia
Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
Osteoarthritis with mild chondrodysplasia
GWAS
Blood protein levels (
30072576
28240269
)
Blood protein levels in cardiovascular risk (
28369058
)
Lymphocyte counts (
32888494
)
Macular thickness (
30535121
)
Monocyte count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Retinal detachment or retinal break (
31816047
)
Rheumatoid arthritis (
30891314
)
Interacting Genes
17 interacting genes:
ACAN
BCAN
BSG
CCL13
CCL2
CCL7
CD44
CMA1
COL2A1
IGFBP3
ITGA2
MMP7
SERPINA3
SOX8
TFPI
TIMP1
TNFSF11
33 interacting genes:
ANXA5
BGN
BMP2
C1QA
CHAD
COL6A1
COL9A2
COL9A3
COMP
DDR1
FGF7
FN1
HTRA1
HYAL1
ITGA2B
KEAP1
LOXL4
MAG
MATN1
MMP1
MMP13
PCOLCE
PDGFA
PDGFB
PDIA2
PKD1
PRELP
RELA
SPARC
TGFB1
TGFBI
THBS1
TNFRSF10A
Entrez ID
4312
1280
HPRD ID
00384
00361
Ensembl ID
ENSG00000196611
ENSG00000139219
Uniprot IDs
B4DN15
P03956
Q53G95
P02458
PDB IDs
1AYK
1CGE
1CGF
1CGL
1HFC
1SU3
2AYK
2CLT
2J0T
2TCL
3AYK
3SHI
4AUO
4AYK
966C
1U5M
2FSE
2SEB
5NIR
5OCX
5OCY
6BIN
6NIX
Enriched GO Terms of Interacting Partners
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