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MMP1 and CCL7
Data Source:
HPRD
(in vitro, in vivo)
MMP1
CCL7
Description
matrix metallopeptidase 1
C-C motif chemokine ligand 7
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Matrix
Extracellular Space
Molecular Function
Endopeptidase Activity
Metalloendopeptidase Activity
Serine-type Endopeptidase Activity
Peptidase Activity
Zinc Ion Binding
Protein Binding
Chemokine Activity
Heparin Binding
CCR1 Chemokine Receptor Binding
CCR2 Chemokine Receptor Binding
CCR Chemokine Receptor Binding
Biological Process
Proteolysis
Viral Process
Cytokine-mediated Signaling Pathway
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Collagen Catabolic Process
Positive Regulation Of Protein-containing Complex Assembly
Cellular Protein Metabolic Process
Leukocyte Migration
Cellular Response To UV-A
Monocyte Chemotaxis
Cellular Calcium Ion Homeostasis
Chemotaxis
Inflammatory Response
Cytoskeleton Organization
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Cell-cell Signaling
Regulation Of Cell Shape
Response To Gamma Radiation
Positive Regulation Of Cell Migration
Neutrophil Chemotaxis
Positive Regulation Of GTPase Activity
Eosinophil Chemotaxis
Lymphocyte Chemotaxis
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Interferon-gamma
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Cellular Response To Ethanol
Positive Regulation Of Natural Killer Cell Chemotaxis
Pathways
Collagen degradation
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Basigin interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Interleukin-4 and Interleukin-13 signaling
Chemokine receptors bind chemokines
Drugs
Marimastat
CGS-27023
N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE
METHYLAMINO-PHENYLALANYL-LEUCYL-HYDROXAMIC ACID
[[1-[N-HYDROXY-ACETAMIDYL]-3-METHYL-BUTYL]-CARBONYL-LEUCINYL]-ALANINE ETHYL ESTER
N-HYDROXY-2-[4-(4-PHENOXY-BENZENESULFONYL)-TETRAHYDRO-PYRAN-4-YL]-ACETAMIDE
Diseases
Choriocarcinoma
GWAS
Blood protein levels (
30072576
28240269
)
Blood protein levels in cardiovascular risk (
28369058
)
Blood protein levels (
30072576
29875488
)
Crohn's disease (
28067908
22412388
21102463
)
Gut microbiota (functional units) (
27694959
)
Inflammatory bowel disease (
28067908
)
Interacting Genes
17 interacting genes:
ACAN
BCAN
BSG
CCL13
CCL2
CCL7
CD44
CMA1
COL2A1
IGFBP3
ITGA2
MMP7
SERPINA3
SOX8
TFPI
TIMP1
TNFSF11
18 interacting genes:
ACKR1
ACKR2
ACKR4
CCR1
CCR10
CCR3
CCR5
CXCL6
FEZ1
MMP1
MMP13
MMP14
MMP2
MMP3
TLE5
UBQLN1
UBQLN2
XCL2
Entrez ID
4312
6354
HPRD ID
00384
01150
Ensembl ID
ENSG00000196611
ENSG00000108688
Uniprot IDs
B4DN15
P03956
Q53G95
P80098
PDB IDs
1AYK
1CGE
1CGF
1CGL
1HFC
1SU3
2AYK
2CLT
2J0T
2TCL
3AYK
3SHI
4AUO
4AYK
966C
1BO0
1NCV
4ZKC
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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