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COL2A1 and MAG
Data Source:
HPRD
(in vitro)
COL2A1
MAG
Description
collagen type II alpha 1 chain
myelin associated glycoprotein
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Collagen Trimer
Collagen Type II Trimer
Basement Membrane
Extracellular Space
Endoplasmic Reticulum Lumen
Extracellular Matrix
Collagen-containing Extracellular Matrix
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Paranode Region Of Axon
Myelin Sheath Adaxonal Region
Myelin Sheath
Compact Myelin
Schmidt-Lanterman Incisure
Membrane Raft
Mesaxon
Molecular Function
Extracellular Matrix Structural Constituent
Extracellular Matrix Structural Constituent Conferring Tensile Strength
MHC Class II Protein Binding
Identical Protein Binding
Proteoglycan Binding
Metal Ion Binding
Platelet-derived Growth Factor Binding
Signaling Receptor Binding
Protein Kinase Binding
Carbohydrate Binding
Sialic Acid Binding
Protein Homodimerization Activity
Ganglioside GT1b Binding
Biological Process
Skeletal System Development
Cartilage Condensation
Tissue Homeostasis
Endochondral Ossification
Chondrocyte Differentiation
Heart Morphogenesis
Proteoglycan Metabolic Process
Central Nervous System Development
Visual Perception
Sensory Perception Of Sound
Regulation Of Gene Expression
Extracellular Matrix Organization
Collagen Fibril Organization
Notochord Development
Inner Ear Morphogenesis
Regulation Of Immune Response
Cartilage Development
Roof Of Mouth Development
Limb Bud Formation
Embryonic Skeletal Joint Morphogenesis
Cartilage Development Involved In Endochondral Bone Morphogenesis
Otic Vesicle Development
Cellular Response To BMP Stimulus
Anterior Head Development
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Cell Adhesion
Negative Regulation Of Neuron Projection Development
Transmission Of Nerve Impulse
Central Nervous System Myelination
Negative Regulation Of Axon Extension
Axon Regeneration
Positive Regulation Of Myelination
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Astrocyte Differentiation
Negative Regulation Of Axonogenesis
Leukocyte Migration
Cellular Response To Mechanical Stimulus
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Pathways
Collagen degradation
Collagen degradation
Extracellular matrix organization
Collagen biosynthesis and modifying enzymes
Signaling by PDGF
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Assembly of collagen fibrils and other multimeric structures
Integrin cell surface interactions
Integrin cell surface interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
ECM proteoglycans
NCAM1 interactions
MET activates PTK2 signaling
Collagen chain trimerization
Axonal growth inhibition (RHOA activation)
Basigin interactions
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Collagenase clostridium histolyticum
Diseases
Type II collagenopathies, including: Achondrogenesis II; Hypochondrogenesis; SED congenita; SMED Strudwick type; Kniest dysplasia; Spondyloperipheral dysplasia; Osteoarthritis with mild chondrodysplasia; Stickler syndrome 1; Platyspondylic skeletal dysplasia, Torrance type; Epiphyseal dysplasia, multiple, with myopia and deafness; Czech dysplasia
Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
Osteoarthritis with mild chondrodysplasia
GWAS
Lymphocyte counts (
32888494
)
Macular thickness (
30535121
)
Monocyte count (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Retinal detachment or retinal break (
31816047
)
Rheumatoid arthritis (
30891314
)
Interacting Genes
33 interacting genes:
ANXA5
BGN
BMP2
C1QA
CHAD
COL6A1
COL9A2
COL9A3
COMP
DDR1
FGF7
FN1
HTRA1
HYAL1
ITGA2B
KEAP1
LOXL4
MAG
MATN1
MMP1
MMP13
PCOLCE
PDGFA
PDGFB
PDIA2
PKD1
PRELP
RELA
SPARC
TGFB1
TGFBI
THBS1
TNFRSF10A
18 interacting genes:
APP
COL1A1
COL2A1
COL3A1
COL4A1
COL5A1
COL6A1
COL9A1
COL9A2
COL9A3
FN1
FYN
MAP1B
MBP
NGFR
PLP1
PRNP
RTN4R
Entrez ID
1280
4099
HPRD ID
00361
01160
Ensembl ID
ENSG00000139219
ENSG00000105695
Uniprot IDs
P02458
P20916
Q53ES7
PDB IDs
1U5M
2FSE
2SEB
5NIR
5OCX
5OCY
6BIN
6NIX
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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