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ORC6 and ORC5
Data Source:
BioGRID
(two hybrid)
ORC6
ORC5
Description
origin recognition complex subunit 6
origin recognition complex subunit 5
Image
GO Annotations
Cellular Component
Origin Recognition Complex
Fibrillar Center
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Membrane
Chromosome, Telomeric Region
Chromatin
Origin Recognition Complex
Nucleus
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Cytosol
Molecular Function
DNA Binding
Protein Binding
Nucleotide Binding
Molecular_function
DNA Replication Origin Binding
Protein Binding
ATP Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
DNA Replication
DNA Replication Initiation
Negative Regulation Of Cell Division
G1/S Transition Of Mitotic Cell Cycle
DNA Replication
DNA Replication Initiation
Regulation Of DNA Replication
Pathways
E2F-enabled inhibition of pre-replication complex formation
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
E2F-enabled inhibition of pre-replication complex formation
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Drugs
Diseases
GWAS
Alcohol consumption (drinks per week) (
30643258
)
Night sleep phenotypes (
27126917
)
Sucrose liking (
31005972
)
Interacting Genes
19 interacting genes:
APP
CDC45
CDC6
CDC7
DBF4
HMGA1
LHX4
MCM2
MCM4
MCM5
MCM6
MCM7
ORC2
ORC3
ORC4
ORC5
RPA1
SPAG5
TERF2
30 interacting genes:
CALCOCO2
CDC45
CDC5L
CDC6
CDC7
DBF4
DMRTA1
H3-4
H4-16
KRT18
LAMB2
MCM2
MCM3
MCM4
MCM5
MCM7
NIF3L1
NONO
ORC1
ORC2
ORC3
ORC4
ORC6
RPA2
SIPA1L2
STAB1
TAX1BP1
TXNDC11
UBQLN4
USP2
Entrez ID
23594
5001
HPRD ID
06237
09086
Ensembl ID
ENSG00000091651
ENSG00000164815
Uniprot IDs
A0A024R6R3
Q9Y5N6
A4D0P7
O43913
Q53FC8
PDB IDs
3M03
6KVG
5UJ7
5UJM
7JPO
7JPP
7JPQ
7JPR
7JPS
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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