MIR138-1 and C1QBP

Data Source:
BioGRID (unspecified method)

		MIR138-1	C1QBP
Description		microRNA 138-1	complement C1q binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Space Nucleus Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Cell Surface Membrane Presynaptic Active Zone Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	MRNA Binding Involved In Posttranscriptional Gene Silencing	Complement Component C1q Complex Binding Transcription Corepressor Activity MRNA Binding Protein Kinase C Binding Protein Binding Hyaluronic Acid Binding Transcription Factor Binding Translation Activator Activity Kininogen Binding Adrenergic Receptor Binding Mitochondrial Ribosome Binding
	Biological Process	Negative Regulation Of Cell Adhesion Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Cell Migration Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Osteoblast Proliferation Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Negative Regulation Of Phosphatidylinositol 3-kinase Activity Plasma Membrane Raft Assembly Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Negative Regulation Of Nitric-oxide Synthase Activity Negative Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Kinase B Signaling Negative Regulation Of Response To Cytokine Stimulus Negative Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of P38MAPK Cascade Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II MRNA Processing Apoptotic Process Immune Response Complement Activation, Classical Pathway Blood Coagulation, Intrinsic Pathway RNA Splicing Phosphatidylinositol 3-kinase Signaling Viral Process Regulation Of Complement Activation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of MDA-5 Signaling Pathway Negative Regulation Of RIG-I Signaling Pathway Mature Ribosome Assembly Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Cell Adhesion Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Defense Response To Virus Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Translation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Trophoblast Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis
Pathways			Apoptotic factor-mediated response Intrinsic Pathway of Fibrin Clot Formation Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function
Drugs			Hyaluronic acid Copper
Diseases
GWAS		Schizophrenia ( 30285260)	Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		67 interacting genes: ADARB1 C1QBP CPSF1 DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FAM98B FUS HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 LARP7 LIN28A LRPPRC MARS1 MATR3 NONO NUDT16L1 NUDT21 PDCD11 PRMT1 PTBP1 PTBP3 PUM1 QARS1 RARS1 RBM14 RBM4 RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SYNCRIP TAF15 TENT2 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX3	99 interacting genes: C1QA CEBPA COIL DUX4 EXOSC6 GAB1 GABRB1 HABP4 HMGB1 HMGB2 HNRNPD HRK KLF1 MAPK1 MAPK3 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MMP14 NFKBIE NFYB PRKCA PRKCD PRKCZ PRKD1 PRRC2A SRSF1 SRSF9 TOP3B YWHAB YWHAG
Entrez ID		406929	708
HPRD ID			03168
Ensembl ID		ENSG00000207954	ENSG00000108561
Uniprot IDs			Q07021
PDB IDs			1P32 3RPX 6SZW
Enriched GO Terms of Interacting Partners?
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