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MIR138-1 and EIF2AK2
Data Source:
BioGRID
(unspecified method)
MIR138-1
EIF2AK2
Description
microRNA 138-1
eukaryotic translation initiation factor 2 alpha kinase 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Nucleus
Cytoplasm
Cytosol
Ribosome
Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
MRNA Binding Involved In Posttranscriptional Gene Silencing
RNA Binding
Double-stranded RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Eukaryotic Translation Initiation Factor 2alpha Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Protein Phosphatase Regulator Activity
Identical Protein Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Negative Regulation Of Cell Adhesion
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Gene Expression
Negative Regulation Of Cell Migration
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Osteoblast Proliferation
Gene Silencing By MiRNA
MiRNA Mediated Inhibition Of Translation
Negative Regulation Of Phosphatidylinositol 3-kinase Activity
Plasma Membrane Raft Assembly
Negative Regulation Of Osteoblast Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Inflammatory Response
Negative Regulation Of Nitric-oxide Synthase Activity
Negative Regulation Of Stress Fiber Assembly
Positive Regulation Of Protein Kinase B Signaling
Negative Regulation Of Response To Cytokine Stimulus
Negative Regulation Of Protein K63-linked Ubiquitination
Negative Regulation Of Sprouting Angiogenesis
Negative Regulation Of P38MAPK Cascade
Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Activation Of MAPKK Activity
Positive Regulation Of Cytokine Production
Protein Phosphorylation
Negative Regulation Of Cell Population Proliferation
Response To Virus
Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation
Negative Regulation Of Translation
Peptidyl-tyrosine Phosphorylation
Mitigation Of Host Immune Response By Virus
Positive Regulation Of Chemokine Production
Positive Regulation Of Stress-activated MAPK Cascade
Negative Regulation Of Osteoblast Proliferation
Cellular Response To Amino Acid Starvation
Response To Interferon-alpha
Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Protein Autophosphorylation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of NIK/NF-kappaB Signaling
Regulation Of Hematopoietic Progenitor Cell Differentiation
Regulation Of Hematopoietic Stem Cell Proliferation
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
ISG15 antiviral mechanism
Inhibition of PKR
Drugs
Fostamatinib
Diseases
GWAS
Schizophrenia (
30285260
)
Glucose homeostasis traits (
25524916
)
Platelet count (
32888494
)
Interacting Genes
67 interacting genes:
ADARB1
C1QBP
CPSF1
DARS1
DDX1
DDX21
DDX3X
DHX36
EIF2AK2
EPRS1
ERAL1
ESRP1
FAM98A
FAM98B
FUS
HNRNPA0
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPF
HNRNPH1
HNRNPH2
HNRNPH3
HNRNPK
HNRNPL
HNRNPM
HNRNPR
IARS1
IGF2BP1
IGF2BP2
IGF2BP3
KARS1
LARP7
LIN28A
LRPPRC
MARS1
MATR3
NONO
NUDT16L1
NUDT21
PDCD11
PRMT1
PTBP1
PTBP3
PUM1
QARS1
RARS1
RBM14
RBM4
RTCB
SF3B1
SF3B2
SF3B3
SF3B4
SFPQ
SPOUT1
STRBP
SYNCRIP
TAF15
TENT2
TRA2A
TRA2B
U2SURP
UPF1
UTP20
YBX1
YBX3
124 interacting genes:
ADARB1
CASP3
CASP7
CASP8
CDC42
CHUK
DHX58
DHX9
DICER1
DNAJC3
EDC4
EIF2A
EIF2S1
EIF6
ELF2
FTSJ3
H2AC20
H2AC4
HSP90AA1
HSPA1A
IKBKB
IL7R
ILF2
ILF3
JAK1
MAP3K5
MAP3K7
METAP2
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
MOV10
NFKBIA
NPM1
PDGFRB
PPP1CA
PPP1CC
PPP2R5A
PRKRA
PRKRIP1
PTGES3
RAC1
STAT1
STAT3
STRBP
SUMO1
TAB2
TARBP2
THAP12
TIRAP
TOLLIP
TP53
TYK2
UBE2I
ZNF346
Entrez ID
406929
5610
HPRD ID
01468
Ensembl ID
ENSG00000207954
ENSG00000055332
Uniprot IDs
P19525
Q8IW76
PDB IDs
1QU6
2A19
2A1A
3UIU
6D3K
6D3L
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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