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LMNB1 and CASP6
Data Source:
HPRD
(in vivo, in vitro)
LMNB1
CASP6
Description
lamin B1
caspase 6
Image
GO Annotations
Cellular Component
Nucleus
Nuclear Envelope
Nuclear Inner Membrane
Lamin Filament
Nucleoplasm
Membrane
Nuclear Matrix
Nuclear Membrane
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Structural Molecule Activity
Protein Binding
Phospholipase Binding
Sequence-specific Double-stranded DNA Binding
Cysteine-type Endopeptidase Activity
Protein Binding
Cysteine-type Peptidase Activity
Identical Protein Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Biological Process
Interleukin-12-mediated Signaling Pathway
Proteolysis
Apoptotic Process
Epithelial Cell Differentiation
Regulation Of Apoptotic Process
Cellular Response To Staurosporine
Execution Phase Of Apoptosis
Pathways
Meiotic synapsis
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Nuclear Envelope Breakdown
Initiation of Nuclear Envelope (NE) Reformation
Breakdown of the nuclear lamina
Depolymerisation of the Nuclear Lamina
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Apoptotic cleavage of cellular proteins
Caspase-mediated cleavage of cytoskeletal proteins
Breakdown of the nuclear lamina
TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS
Blood protein levels (
30072576
29875488
)
Body fat percentage (
31752434
)
Parkinson's disease (motor and cognition) (
22658654
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Interacting Genes
44 interacting genes:
ABCG8
ATF4
CASP3
CASP6
CCDC88B
CDK1
CENPH
DMAP1
FAM169A
GABARAP
GIT2
GZMA
GZMB
KPNA1
KPNA5
KPNA6
LBR
LMNA
LMNB2
M1AP
MAP1LC3A
MAP1LC3C
MBIP
MELK
PIAS2
PIH1D2
PLEC
PPP1R13B
PRKCA
PRKCB
PRKCD
PRPH
PTEN
RNF123
SERPINA3
SNAPIN
SRPK2
SUMO4
TMPO
TOR1AIP1
TP53BP2
UBE2I
URB2
YWHAQ
42 interacting genes:
APP
CASP10
CASP3
CASP8
CFLAR
CHD3
COPS6
DSP
EIF2S1
HTT
IKBKG
KRT18
LMNA
LMNB1
LNX1
MAPK6
MAPT
NEDD4
NTAQ1
NUAK1
PCYT1A
PIN1
PKIA
PPL
PRKAB2
PRKCZ
PSEN1
PSEN2
PSME3
RB1
SATB1
SP1
SRF
SRP72
STUB1
TAB1
TFAP2A
TOP1
TRAF1
UBE4A
UBE4B
VIM
Entrez ID
4001
839
HPRD ID
01036
03321
Ensembl ID
ENSG00000113368
ENSG00000138794
Uniprot IDs
B4DZT3
P20700
P55212
PDB IDs
2KPW
3JT0
3TYY
3UMN
5VVX
1MI9
2WDP
3K7E
3NKF
3NR2
3OD5
3P45
3P4U
3QNW
3S70
3S8E
3V6L
3V6M
4EJF
4FXO
4HVA
4IYR
4N5D
4N6G
4N7J
4N7M
4NBK
4NBL
4NBN
6DEU
6DEV
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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