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LIG4 and CAP1
Data Source:
BioGRID
(two hybrid)
LIG4
CAP1
Description
DNA ligase 4
cyclase associated actin cytoskeleton regulatory protein 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Condensed Chromosome
Nucleus
Nucleoplasm
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
DNA Ligase IV Complex
Cytoplasmic Ribonucleoprotein Granule
Nonhomologous End Joining Complex
Extracellular Region
Cytoplasm
Plasma Membrane
Focal Adhesion
Cortical Actin Cytoskeleton
Azurophil Granule Lumen
Extracellular Exosome
Molecular Function
DNA Binding
DNA Ligase Activity
DNA Ligase (ATP) Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Ligase Activity
Metal Ion Binding
Actin Binding
Adenylate Cyclase Binding
Biological Process
Single Strand Break Repair
In Utero Embryonic Development
Pro-B Cell Differentiation
DNA Replication
DNA Ligation
Nucleotide-excision Repair, DNA Gap Filling
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cell Cycle
Central Nervous System Development
Cell Population Proliferation
Response To X-ray
Response To Gamma Radiation
T Cell Differentiation In Thymus
V(D)J Recombination
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Somatic Stem Cell Population Maintenance
Negative Regulation Of Neuron Apoptotic Process
Isotype Switching
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Neurogenesis
DNA Ligation Involved In DNA Recombination
DNA Ligation Involved In DNA Repair
Chromosome Organization
Cell Division
Neuron Apoptotic Process
Cellular Response To Lithium Ion
Cellular Response To Ionizing Radiation
DNA Biosynthetic Process
Establishment Of Integrated Proviral Latency
Double-strand Break Repair Via Classical Nonhomologous End Joining
Positive Regulation Of Chromosome Organization
Cell Morphogenesis
Ameboidal-type Cell Migration
Receptor-mediated Endocytosis
Establishment Or Maintenance Of Cell Polarity
Signal Transduction
Activation Of Adenylate Cyclase Activity
CAMP-mediated Signaling
Actin Cytoskeleton Organization
Neutrophil Degranulation
Regulation Of Adenylate Cyclase Activity
Pathways
2-LTR circle formation
Nonhomologous End-Joining (NHEJ)
Platelet degranulation
Role of ABL in ROBO-SLIT signaling
Neutrophil degranulation
Drugs
Diseases
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS
Attention deficit hyperactivity disorder and conduct disorder (
18951430
)
Irritable bowel syndrome (
29626450
)
Refractive error (
32231278
)
Interacting Genes
103 interacting genes:
ACTG1
AFTPH
AGAP4
ALMS1
AMZ2P1
ANAPC10
APLF
ASPM
ATM
ATP6V0D1
ATR
B9D1
BBOF1
CAP1
CLU
COL1A2
COMMD1
CPNE1
CREBBP
CTSK
DDX19A
DGUOK
DPP3
EIF2AK1
EIF3I
EIF4A1
EIF4G3
ENO1
ETF1
FAM214A
FBLL1
FIP1L1
GAPDH
GGH
GPANK1
GRHPR
GUSBP3
GZMK
HMGN1
HNRNPA2B1
IPP
KDELR1
KIF3A
LAP3
MAP2K2
MCM4
MCRS1
MRPS18C
MT-CO1
MT-CO2
MT-CO3
MT-ND1
MT-ND4
MT-ND5
NDUFA13
NDUFB10
NEU1
NHEJ1
NOMO3
NPC2
OGFOD1
OSTM1
OXR1
PA2G4
PALLD
PEX10
PGP
PHF10
PMS2P1
PPIA
PRKDC
PSMA6
RBM5
RHBDD2
RPL11
RPS19BP1
RUVBL2
SEMA4G
SMC2
SNX3
SOWAHC
SRSF2
SYCP3
THOC5
TLE4
TOP1
TP53BP1
TPT1
TRAPPC3
TSFM
UBB
UBE2L3
UFSP2
UNC119
VKORC1
WARS1
WBP1L
WDR20
XRCC4
ZFAND2A
ZNF428
ZSCAN18
ZWINT
9 interacting genes:
ACTB
ACTG1
BARD1
CAP2
LIG4
MYOC
PLA2G4A
SERPINB8
UCHL5
Entrez ID
3981
10487
HPRD ID
03500
09869
Ensembl ID
ENSG00000174405
ENSG00000131236
Uniprot IDs
A0A024RE06
A0A0C4DGV9
A8K8Q4
P49917
D3DPU2
Q01518
PDB IDs
1IK9
2E2W
3II6
3VNN
3W1B
3W1G
3W5O
4HTO
4HTP
6BKF
6BKG
1K8F
Enriched GO Terms of Interacting Partners
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