LIG4 and PALLD

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		LIG4	PALLD
Description		DNA ligase 4	palladin, cytoskeletal associated protein
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Condensed Chromosome Nucleus Nucleoplasm DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Cytoplasmic Ribonucleoprotein Granule Nonhomologous End Joining Complex	Stress Fiber Ruffle Podosome Nucleus Cytosol Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium Axon Growth Cone Excitatory Synapse
	Molecular Function	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Protein C-terminus Binding Ligase Activity Metal Ion Binding	Actin Binding Protein Binding Muscle Alpha-actinin Binding Cell-cell Adhesion Mediator Activity
	Biological Process	Single Strand Break Repair In Utero Embryonic Development Pro-B Cell Differentiation DNA Replication DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Central Nervous System Development Cell Population Proliferation Response To X-ray Response To Gamma Radiation T Cell Differentiation In Thymus V(D)J Recombination Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Somatic Stem Cell Population Maintenance Negative Regulation Of Neuron Apoptotic Process Isotype Switching Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis DNA Ligation Involved In DNA Recombination DNA Ligation Involved In DNA Repair Chromosome Organization Cell Division Neuron Apoptotic Process Cellular Response To Lithium Ion Cellular Response To Ionizing Radiation DNA Biosynthetic Process Establishment Of Integrated Proviral Latency Double-strand Break Repair Via Classical Nonhomologous End Joining Positive Regulation Of Chromosome Organization	Keratinocyte Development Epithelial Cell Morphogenesis Cytoskeleton Organization Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Axon Guidance Cell Migration Actin Cytoskeleton Organization Dendrite Self-avoidance
Pathways		2-LTR circle formation Nonhomologous End-Joining (NHEJ)
Drugs
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Irritable bowel syndrome ( 29626450)	Advanced glycation end-product levels ( 26915486) Bacteremia ( 27236921) Coronary artery disease ( 29212778 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Non-alcoholic fatty liver disease histology (AST) ( 20708005) Pulse pressure ( 28135244 27841878 30578418) Response to iloperidone treatment (QT prolongation) ( 18521091) Systolic blood pressure ( 30578418) Vein graft stenosis in coronary artery bypass grafting ( 25881214)
Interacting Genes		103 interacting genes: ACTG1 AFTPH AGAP4 ALMS1 AMZ2P1 ANAPC10 APLF ASPM ATM ATP6V0D1 ATR B9D1 BBOF1 CAP1 CLU COL1A2 COMMD1 CPNE1 CREBBP CTSK DDX19A DGUOK DPP3 EIF2AK1 EIF3I EIF4A1 EIF4G3 ENO1 ETF1 FAM214A FBLL1 FIP1L1 GAPDH GGH GPANK1 GRHPR GUSBP3 GZMK HMGN1 HNRNPA2B1 IPP KDELR1 KIF3A LAP3 MAP2K2 MCM4 MCRS1 MRPS18C MT-CO1 MT-CO2 MT-CO3 MT-ND1 MT-ND4 MT-ND5 NDUFA13 NDUFB10 NEU1 NHEJ1 NOMO3 NPC2 OGFOD1 OSTM1 OXR1 PA2G4 PALLD PEX10 PGP PHF10 PMS2P1 PPIA PRKDC PSMA6 RBM5 RHBDD2 RPL11 RPS19BP1 RUVBL2 SEMA4G SMC2 SNX3 SOWAHC SRSF2 SYCP3 THOC5 TLE4 TOP1 TP53BP1 TPT1 TRAPPC3 TSFM UBB UBE2L3 UFSP2 UNC119 VKORC1 WARS1 WBP1L WDR20 XRCC4 ZFAND2A ZNF428 ZSCAN18 ZWINT	12 interacting genes: ACTN1 ACTN2 CDC42 EZR HOMER2 HOMER3 ITGB5 LIG4 PDLIM3 SORBS2 SRPK2 SUMO2
Entrez ID		3981	23022
HPRD ID		03500	09731
Ensembl ID		ENSG00000174405	ENSG00000129116
Uniprot IDs		A0A024RE06 A0A0C4DGV9 A8K8Q4 P49917	B2RTX2 Q8WX93
PDB IDs		1IK9 2E2W 3II6 3VNN 3W1B 3W1G 3W5O 4HTO 4HTP 6BKF 6BKG	2DM2 2DM3
Enriched GO Terms of Interacting Partners?
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