CAP1 and PLA2G4A

Data Source:
BioGRID (two hybrid)

		CAP1	PLA2G4A
Description		cyclase associated actin cytoskeleton regulatory protein 1	phospholipase A2 group IVA
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Focal Adhesion Cortical Actin Cytoskeleton Azurophil Granule Lumen Extracellular Exosome	Golgi Membrane Nucleus Nuclear Envelope Cytoplasm Mitochondrial Inner Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Actin Binding Adenylate Cyclase Binding	Lysophospholipase Activity Phospholipase A2 Activity Calcium Ion Binding Calcium-dependent Phospholipid Binding O-acyltransferase Activity Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Calcium-dependent Phospholipase A2 Activity Calcium-independent Phospholipase A2 Activity Phosphatidylinositol-4-phosphate Binding Phosphatidyl Phospholipase B Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine) Ceramide 1-phosphate Binding
	Biological Process	Cell Morphogenesis Ameboidal-type Cell Migration Receptor-mediated Endocytosis Establishment Or Maintenance Of Cell Polarity Signal Transduction Activation Of Adenylate Cyclase Activity CAMP-mediated Signaling Actin Cytoskeleton Organization Neutrophil Degranulation Regulation Of Adenylate Cyclase Activity	Prostaglandin Biosynthetic Process Positive Regulation Of T-helper 1 Type Immune Response Glycerol Metabolic Process Monoacylglycerol Biosynthetic Process Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Platelet Activating Factor Biosynthetic Process Icosanoid Metabolic Process Positive Regulation Of Platelet Activation Arachidonic Acid Metabolic Process Leukotriene Biosynthetic Process Positive Regulation Of Prostaglandin Secretion Phosphatidylglycerol Catabolic Process Phosphatidylcholine Catabolic Process Cardiolipin Acyl-chain Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Regulation Of Cell Population Proliferation Positive Regulation Of Macrophage Activation Glycerophospholipid Catabolic Process Arachidonic Acid Secretion Cellular Response To Antibiotic
Pathways		Platelet degranulation Role of ABL in ROBO-SLIT signaling Neutrophil degranulation	phospho-PLA2 pathway Acyl chain remodelling of PC Acyl chain remodeling of CL Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Hydrolysis of LPC Synthesis of PA Arachidonic acid metabolism ADP signalling through P2Y purinoceptor 1 Platelet sensitization by LDL COPI-independent Golgi-to-ER retrograde traffic
Drugs			Fluticasone propionate Procaine Quinacrine Niflumic acid Darapladib Fluticasone
Diseases
GWAS		Refractive error ( 32231278)	Blood urea nitrogen levels ( 31152163) Body size at age 10 ( 32376654) Crohn's disease ( 26192919) Estimated glomerular filtration rate ( 31152163) Generalized epilepsy ( 22949513) Hip circumference adjusted for BMI ( 28552196) Hyperinsulinemia in less-fat diet ( 30327367) Hyperinsulinemia x saturated fatty acids interaction ( 30327367) Inflammatory bowel disease ( 26192919) Knee osteoarthritis ( 18471798) Non-del(5q) myelodysplastic syndromes ( 31738830) Uterine fibroid size (maximum volume) ( 30196971) Zinc levels ( 26025379)
Interacting Genes		9 interacting genes: ACTB ACTG1 BARD1 CAP2 LIG4 MYOC PLA2G4A SERPINB8 UCHL5	24 interacting genes: ANXA2 BORCS6 CAP1 CASP1 CASP3 CASP4 ITGA2B ITGB3 JAK1 KAT5 MAPK1 MAPK14 MAPKAPK5 MKNK1 NCF1 PLA2G5 PRKCA RELA RPS6KA5 SHBG SIRT2 UBXN1 VIM XAGE1B
Entrez ID		10487	5321
HPRD ID		09869	08986
Ensembl ID		ENSG00000131236	ENSG00000116711
Uniprot IDs		D3DPU2 Q01518	B4DZI4 P47712
PDB IDs		1K8F	1BCI 1CJY 1RLW
Enriched GO Terms of Interacting Partners?
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