ACAT1 and PDP1

Data Source:
BioGRID (pull down)

		ACAT1	PDP1
Description		acetyl-CoA acetyltransferase 1	pyruvate dehydrogenase phosphatase catalytic subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Extracellular Exosome	Mitochondrion Mitochondrial Matrix
	Molecular Function	Acetyl-CoA C-acetyltransferase Activity C-acetyltransferase Activity Potassium Ion Binding	Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity [pyruvate Dehydrogenase (lipoamide)] Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Acetyl-CoA Biosynthetic Process Isoleucine Catabolic Process Fatty Acid Beta-oxidation Branched-chain Amino Acid Catabolic Process Coenzyme A Metabolic Process Coenzyme A Biosynthetic Process Cholesterol Esterification Acetyl-CoA Catabolic Process Ketone Body Biosynthetic Process Ketone Body Catabolic Process Ketone Body Metabolic Process Propionyl-CoA Biosynthetic Process	Protein Dephosphorylation Regulation Of Acetyl-CoA Biosynthetic Process From Pyruvate Peptidyl-threonine Dephosphorylation Positive Regulation Of Pyruvate Dehydrogenase Activity
Pathways		Branched-chain amino acid catabolism Utilization of Ketone Bodies Synthesis of Ketone Bodies	Regulation of pyruvate dehydrogenase (PDH) complex
Drugs		Sulfasalazine Cannabidiol Medical Cannabis Nabiximols
Diseases			Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Nonunion in individuals with fractures ( 30680360) Refractive error ( 32231278)
Interacting Genes		4 interacting genes: AGXT PDP1 PEX7 PTPRF	10 interacting genes: ACAT1 CBFA2T2 EGFR FGFR1 INCA1 KRTAP6-2 MEOX2 PDHA1 PRKCD SIRT3
Entrez ID		38	54704
HPRD ID		01946	16185
Ensembl ID		ENSG00000075239	ENSG00000164951
Uniprot IDs		A0A140VJX1 A0A5F9ZHJ0 P24752	A0A024R9C0 Q6P1N1 Q9P0J1
PDB IDs		2F2S 2IB7 2IB8 2IB9 2IBU 2IBW 2IBY
Enriched GO Terms of Interacting Partners?
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