IL17A and DPH2

Data Source:
BioGRID (two hybrid)

		IL17A	DPH2
Description		interleukin 17A	diphthamide biosynthesis 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Cytosol
	Molecular Function	Cytokine Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Protein Binding 2-(3-amino-3-carboxypropyl)histidine Synthase Activity
	Biological Process	Positive Regulation Of Antimicrobial Peptide Production Adaptive Immune Response Apoptotic Process Inflammatory Response Immune Response Cell-cell Signaling Cell Death Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-16 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Intestinal Epithelial Structure Maintenance Cellular Response To Interleukin-1 Fibroblast Activation Interleukin-17-mediated Signaling Pathway Granulocyte Migration Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production	Peptidyl-diphthamide Biosynthetic Process From Peptidyl-histidine
Pathways		Interleukin-17 signaling Interleukin-4 and Interleukin-13 signaling	Synthesis of diphthamide-EEF2
Drugs		Secukinumab Ixekizumab
Diseases
GWAS		Height ( 28552196)	Autism spectrum disorder or schizophrenia ( 28540026)
Interacting Genes		3 interacting genes: DPH2 IL17RA KCNIP4	7 interacting genes: CRYGA FARS2 IL17A MAGOH MISP NEK6 TNK2
Entrez ID		3605	1802
HPRD ID		04396	16023
Ensembl ID		ENSG00000112115	ENSG00000132768
Uniprot IDs		Q16552	B3KRB8 Q9BQC3
PDB IDs		2VXS 4HR9 4HSA 4QHU 5HHV 5HHX 5HI3 5HI4 5HI5 5N7W 5N92 5NAN 5VB9 6WIO 6WIR
Enriched GO Terms of Interacting Partners?
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