IL17A and IL17RA

Data Source:
HPRD (in vivo, in vitro)

		IL17A	IL17RA
Description		interleukin 17A	interleukin 17 receptor A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Cytokine Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Protein Binding Interleukin-17 Receptor Activity
	Biological Process	Positive Regulation Of Antimicrobial Peptide Production Adaptive Immune Response Apoptotic Process Inflammatory Response Immune Response Cell-cell Signaling Cell Death Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-16 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Innate Immune Response Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Defense Response To Fungus Intestinal Epithelial Structure Maintenance Cellular Response To Interleukin-1 Fibroblast Activation Interleukin-17-mediated Signaling Pathway Granulocyte Migration Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Bicellular Tight Junction Assembly Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production	Adaptive Immune Response Inflammatory Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Innate Immune Response Fibroblast Activation Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production
Pathways		Interleukin-17 signaling Interleukin-4 and Interleukin-13 signaling	Interleukin-17 signaling
Drugs		Secukinumab Ixekizumab
Diseases			Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS		Height ( 28552196)	Blood protein levels ( 30072576 29875488 28240269) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Heschl's gyrus morphology ( 25130324) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) White blood cell count ( 32888494 27863252)
Interacting Genes		3 interacting genes: DPH2 IL17RA KCNIP4	2 interacting genes: IL17A MTDH
Entrez ID		3605	23765
HPRD ID		04396	10399
Ensembl ID		ENSG00000112115	ENSG00000177663
Uniprot IDs		Q16552	Q96F46
PDB IDs		2VXS 4HR9 4HSA 4QHU 5HHV 5HHX 5HI3 5HI4 5HI5 5N7W 5N92 5NAN 5VB9 6WIO 6WIR	3JVF 4HSA 4NUX 5N9B 5NAN
Enriched GO Terms of Interacting Partners?
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