IGHG1 and CD40LG

Data Source:
HPRD (in vitro)

		IGHG1	CD40LG
Description		immunoglobulin heavy constant gamma 1 (G1m marker)	CD40 ligand
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane Immunoglobulin Complex, Circulating Extracellular Exosome Blood Microparticle	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Antigen Binding Protein Binding Immunoglobulin Receptor Binding	Cytokine Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Integrin Binding Protein Binding
	Biological Process	Phagocytosis, Recognition Phagocytosis, Engulfment Complement Activation Complement Activation, Classical Pathway Cytokine-mediated Signaling Pathway Regulation Of Complement Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Defense Response To Bacterium Innate Immune Response B Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation	Regulation Of Immunoglobulin Production Inflammatory Response Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Activation Of JUN Kinase Activity CD40 Signaling Pathway Platelet Activation B Cell Differentiation T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-4 Production Tumor Necrosis Factor-mediated Signaling Pathway B Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Isotype Switching Regulation Of Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs			Ruplizumab
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Blood protein levels ( 29875488) Composite immunoglobulin trait (IgG/IgM) ( 28628107) IgG levels ( 23225573)	CD40 ligand levels ( 25147954) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Pediatric autoimmune diseases ( 26301688) Plateletcrit ( 32888494)
Interacting Genes		7 interacting genes: CD40LG FCGR3A FCGR3B IGKC SWAP70 TRIM21 UCHL5	6 interacting genes: CD40 CD5L IGHG1 IGKC RNF128 TP53
Entrez ID		3500	959
HPRD ID		11755	02311
Ensembl ID		ENSG00000211896	ENSG00000102245
Uniprot IDs			P29965
PDB IDs			1ALY 1I9R 3LKJ 3QD6 6BRB
Enriched GO Terms of Interacting Partners?
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