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IGHG1 and TRIM21
Data Source:
BioGRID
(pull down, affinity chromatography technology)
IGHG1
TRIM21
Description
immunoglobulin heavy constant gamma 1 (G1m marker)
tripartite motif containing 21
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
External Side Of Plasma Membrane
Immunoglobulin Complex, Circulating
Extracellular Exosome
Blood Microparticle
P-body
Nucleus
Nucleoplasm
Cytoplasm
Autophagosome
Cytosol
SCF Ubiquitin Ligase Complex
Cytoplasmic Vesicle
Ribonucleoprotein Complex
Molecular Function
Antigen Binding
Protein Binding
Immunoglobulin Receptor Binding
DNA Binding
Transcription Coactivator Activity
RNA Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin Protein Ligase Activity
Biological Process
Phagocytosis, Recognition
Phagocytosis, Engulfment
Complement Activation
Complement Activation, Classical Pathway
Cytokine-mediated Signaling Pathway
Regulation Of Complement Activation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Defense Response To Bacterium
Innate Immune Response
B Cell Receptor Signaling Pathway
Positive Regulation Of B Cell Activation
Protein Polyubiquitination
Protein Monoubiquitination
Cell Cycle
Regulation Of Gene Expression
Positive Regulation Of Autophagy
Protein Ubiquitination
Protein Destabilization
Negative Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Protein Binding
Regulation Of Type I Interferon Production
Regulation Of Protein Localization
Negative Regulation Of Viral Transcription
Response To Interferon-gamma
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Positive Regulation Of Cell Cycle
Negative Regulation Of Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Regulation Of Viral Entry Into Host Cell
Positive Regulation Of Viral Entry Into Host Cell
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Autoubiquitination
Interferon-gamma-mediated Signaling Pathway
Protein K63-linked Ubiquitination
Negative Regulation Of Protein Deubiquitination
Negative Regulation Of Viral Release From Host Cell
Pathways
STING mediated induction of host immune responses
Regulation of innate immune responses to cytosolic DNA
Interferon gamma signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Blood protein levels (
29875488
)
Composite immunoglobulin trait (IgG/IgM) (
28628107
)
IgG levels (
23225573
)
Lung cancer (
28604730
)
Malaria (
31844061
)
Interacting Genes
7 interacting genes:
CD40LG
FCGR3A
FCGR3B
IGKC
SWAP70
TRIM21
UCHL5
71 interacting genes:
ALOX15B
APC
CALR
CASP8AP2
CBX4
CDC34
CUL1
CWC25
DAXX
DCP2
DMAP1
DZIP3
EHHADH
EXOC8
FADD
FBXW11
FHOD1
GABARAP
GABARAPL1
GABARAPL2
GMCL1
GRAP
HLA-DRB1
IGFN1
IGHG1
IGHV4-31
IKBKB
IRF5
IRF8
LNX1
MAP1LC3A
MAP1LC3B
MAP1LC3C
MNAT1
NIF3L1
PFKP
RBCK1
RNF111
RO60
SAMHD1
SETD7
SKP2
SQSTM1
TBK1
TCP11L1
TNS4
TRIM27
TRIM3
TRIM39
TRIM5
TRIM8
TXN2
UBC
UBE2C
UBE2D1
UBE2D2
UBE2E1
UBE2H
UBE2I
UBE2L3
UBE2N
UBE2V2
UBE2W
USP15
USP2
USP4
VPS9D1
XAF1
YJU2
YWHAZ
ZBTB16
Entrez ID
3500
6737
HPRD ID
11755
00170
Ensembl ID
ENSG00000211896
ENSG00000132109
Uniprot IDs
P19474
PDB IDs
2IWG
5JPX
5OLM
6FGA
6S53
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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