CD40LG

Description		CD40 ligand
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GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Cytokine Activity Tumor Necrosis Factor Receptor Binding CD40 Receptor Binding Integrin Binding Protein Binding
	Biological Process	Regulation Of Immunoglobulin Production Inflammatory Response Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Activation Of JUN Kinase Activity CD40 Signaling Pathway Platelet Activation B Cell Differentiation T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-4 Production Tumor Necrosis Factor-mediated Signaling Pathway B Cell Proliferation Positive Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Isotype Switching Regulation Of Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs		Ruplizumab
Diseases		Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		CD40 ligand levels ( 25147954) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Pediatric autoimmune diseases ( 26301688) Plateletcrit ( 32888494)
Interacting Genes		6 interacting genes: CD40 CD5L IGHG1 IGKC RNF128 TP53
Entrez ID		959
HPRD ID		02311
Ensembl ID		ENSG00000102245
Uniprot IDs		P29965
PDB IDs		1ALY 1I9R 3LKJ 3QD6 6BRB
Enriched GO Terms of Interacting Partners?
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