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IGF1 and CCN3
Data Source:
HPRD
(in vitro)
IGF1
CCN3
Description
insulin like growth factor 1
cellular communication network factor 3
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Insulin-like Growth Factor Binding Protein Complex
Platelet Alpha Granule Lumen
Alphav-beta3 Integrin-IGF-1-IGF1R Complex
Insulin-like Growth Factor Ternary Complex
Exocytic Vesicle
Extracellular Region
Cytoplasm
Gap Junction
Axon
Dendrite
Extracellular Matrix
Neuronal Cell Body
Intracellular Membrane-bounded Organelle
Collagen-containing Extracellular Matrix
Molecular Function
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Integrin Binding
Hormone Activity
Protein Binding
Growth Factor Activity
Notch Binding
Integrin Binding
Protein Binding
Insulin-like Growth Factor Binding
Growth Factor Activity
Heparin Binding
Biological Process
Activation Of MAPK Activity
Skeletal System Development
Cell Activation
Platelet Degranulation
Signal Transduction
Ras Protein Signal Transduction
Muscle Organ Development
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Response To Heat
Glycolate Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of Glycoprotein Biosynthetic Process
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Skeletal Muscle Satellite Cell Maintenance Involved In Skeletal Muscle Regeneration
Muscle Hypertrophy
Myotube Cell Development
Positive Regulation Of Smooth Muscle Cell Migration
Proteoglycan Biosynthetic Process
Positive Regulation Of Cell Migration
Activation Of Protein Kinase B Activity
Negative Regulation Of Interleukin-1 Beta Production
Negative Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Smooth Muscle Cell Apoptotic Process
Bone Mineralization Involved In Bone Maturation
Regulation Of Multicellular Organism Growth
Wound Healing
Positive Regulation Of Activated T Cell Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Negative Regulation Of Apoptotic Process
Positive Regulation Of DNA Binding
Positive Regulation Of MAPK Cascade
Protein Kinase B Signaling
Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway
Cellular Protein Metabolic Process
Myoblast Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Glycolytic Process
Positive Regulation Of Mitotic Nuclear Division
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Glucose Import
Positive Regulation Of Ras Protein Signal Transduction
Insulin-like Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Secretion
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Protein Stabilization
Myoblast Proliferation
Negative Regulation Of Oocyte Development
Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
ERK1 And ERK2 Cascade
Positive Regulation Of Calcineurin-NFAT Signaling Cascade
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Negative Regulation Of Neuroinflammatory Response
Negative Regulation Of Amyloid-beta Formation
Positive Regulation Of Trophectodermal Cell Proliferation
Cellular Response To Amyloid-beta
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Positive Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Angiogenesis
Chondrocyte Differentiation
Cell Adhesion
Signal Transduction
Regulation Of Gene Expression
Fibroblast Migration
Negative Regulation Of Myotube Differentiation
Smooth Muscle Cell Migration
Negative Regulation Of Cell Growth
Cell Adhesion Mediated By Integrin
Endothelial Cell Chemotaxis
Type B Pancreatic Cell Proliferation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Insulin Secretion
Smooth Muscle Cell Proliferation
Negative Regulation Of Inflammatory Response
Cell Chemotaxis
Negative Regulation Of SMAD Protein Signal Transduction
Negative Regulation Of Cell Death
Hematopoietic Stem Cell Homeostasis
Endothelial Cell-cell Adhesion
Negative Regulation Of Monocyte Chemotaxis
Negative Regulation Of NIK/NF-kappaB Signaling
Negative Regulation Of Chondrocyte Proliferation
Negative Regulation Of Sensory Perception Of Pain
Bone Regeneration
Pathways
Platelet degranulation
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
IRS-related events triggered by IGF1R
SHC-related events triggered by IGF1R
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Synthesis, secretion, and deacylation of Ghrelin
Drugs
N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide
N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate
Insulin pork
Diseases
Malignant pleural mesothelioma
Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
Birth weight (
31043758
27680694
)
Brain morphology (MOSTest) (
32665545
)
Dental caries (decayed and filled deciduous teeth) (
31533690
)
Fasting blood insulin (
20081858
22581228
)
Fasting blood insulin (BMI interaction) (
22581228
)
FEV1 (
30804560
)
Height (
25429064
19893584
31562340
31217584
20189936
)
Homeostasis model assessment of insulin resistance (
20081858
)
Insulin-related traits (multivariate analysis) (
32002517
)
Intraocular pressure (
29617998
29785010
)
Lung function (FVC) (
30804560
)
Mammographic density (dense area) (
25342443
)
Offspring birth weight (
31043758
)
Peak expiratory flow (
30804560
)
Refractive error (
32231278
)
Response to quetiapine in schizophrenia (
29503163
)
Systolic blood pressure (
30224653
)
Thiazide-induced adverse metabolic effects in hypertensive patients (
23400010
)
Interacting Genes
22 interacting genes:
BANP
CCN3
CCN5
CTSB
E2F1
ENKD1
IDE
IGF1R
IGFALS
IGFBP1
IGFBP2
IGFBP3
IGFBP4
IGFBP5
IGFBP6
IGFBP7
IGSF1
MESD
MKRN3
SOX4
TCEANC
TF
29 interacting genes:
ADSL
ANKRD11
APOL6
C11orf87
CCN2
CDKN1A
COL8A1
DLL1
FAM90A1
FBLN1
FN1
FRS3
GJA1
HOXA1
IGF1
IGF2
INS
ITGAV
KRTAP5-6
LCE1A
LCE3D
NID2
NOTCH1
POLR2L
POU4F2
RECK
S100A4
TNIP3
ZNF330
Entrez ID
3479
4856
HPRD ID
00936
01291
Ensembl ID
ENSG00000017427
ENSG00000136999
Uniprot IDs
P05019
Q13429
Q59GC5
Q5U743
A0A024R9J4
P48745
PDB IDs
1B9G
1BQT
1GF1
1GZR
1GZY
1GZZ
1H02
1H59
1IMX
1PMX
1TGR
1WQJ
2DSP
2DSQ
2DSR
2GF1
3GF1
3LRI
4XSS
5U8Q
6FF3
6PYH
6RVA
Enriched GO Terms of Interacting Partners
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