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NR3C1 and HSPA1A
Data Source:
HPRD
(in vivo)
NR3C1
HSPA1A
Description
nuclear receptor subfamily 3 group C member 1
heat shock protein family A (Hsp70) member 1A
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Matrix
Microtubule Organizing Center
Spindle
Cytosol
Nuclear Speck
Protein-containing Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Centrosome
Centriole
Cytosol
Plasma Membrane
Focal Adhesion
COP9 Signalosome
Inclusion Body
Aggresome
Nuclear Speck
Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Blood Microparticle
Ficolin-1-rich Granule Lumen
Ribonucleoprotein Complex
Molecular Function
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Core Promoter Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
RNA Binding
Nuclear Receptor Activity
Glucocorticoid Receptor Activity
Steroid Binding
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Hsp90 Protein Binding
Steroid Hormone Binding
Sequence-specific Double-stranded DNA Binding
Virus Receptor Activity
G Protein-coupled Receptor Binding
Transcription Corepressor Activity
RNA Binding
Signaling Receptor Binding
Protein Binding
ATP Binding
ATPase Activity
Enzyme Binding
Heat Shock Protein Binding
Denatured Protein Binding
Ubiquitin Protein Ligase Binding
Histone Deacetylase Binding
Protein Folding Chaperone
Cadherin Binding
Protein N-terminus Binding
Unfolded Protein Binding
Misfolded Protein Binding
C3HC4-type RING Finger Domain Binding
Disordered Domain Specific Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Apoptotic Process
Cell Cycle
Chromosome Segregation
Signal Transduction
Intracellular Steroid Hormone Receptor Signaling Pathway
Glucocorticoid Receptor Signaling Pathway
Glucocorticoid Mediated Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Cell Division
Cellular Response To Steroid Hormone Stimulus
Cellular Response To Glucocorticoid Stimulus
Cellular Response To Dexamethasone Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
MRNA Catabolic Process
Response To Unfolded Protein
Lysosomal Transport
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Regulation Of Cell Death
Vesicle-mediated Transport
Negative Regulation Of Cell Growth
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Protein Ubiquitination
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of RNA Splicing
Cellular Response To Oxidative Stress
Cellular Response To Heat
Cellular Response To Unfolded Protein
Protein Refolding
Negative Regulation Of Apoptotic Process
Neutrophil Degranulation
Regulation Of MRNA Stability
Positive Regulation Of Erythrocyte Differentiation
ATP Metabolic Process
Viral Entry Into Host Cell
Protein Stabilization
Chaperone Cofactor-dependent Protein Refolding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Chaperone-mediated Protein Complex Assembly
Negative Regulation Of Cell Death
Cellular Heat Acclimation
Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Positive Regulation Of Microtubule Nucleation
Negative Regulation Of Inclusion Body Assembly
Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of Cellular Response To Heat
Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Regulation Of Mitotic Spindle Assembly
Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Endoribonuclease Activity
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Circadian Clock
SUMOylation of intracellular receptors
PTK6 Expression
Regulation of RUNX2 expression and activity
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Potential therapeutics for SARS
Viral RNP Complexes in the Host Cell Nucleus
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
AUF1 (hnRNP D0) binds and destabilizes mRNA
Neutrophil degranulation
Regulation of HSF1-mediated heat shock response
HSP90 chaperone cycle for steroid hormone receptors (SHR)
Attenuation phase
HSF1-dependent transactivation
Neutrophil degranulation
Drugs
Flunisolide
Diflorasone
Alclometasone
Medrysone
Amcinonide
Fluorometholone
Megestrol acetate
Levonorgestrel
Beclomethasone dipropionate
Progesterone
Spironolactone
Betamethasone
Desoximetasone
Fluticasone propionate
Fluocinolone acetonide
Ulobetasol
Triamcinolone
Prednisone
Flumethasone
Fludrocortisone
Norethisterone
Hydrocortisone
Mometasone
Hydrocortamate
Mifepristone
Clocortolone
Flurandrenolide
Prednisolone
Loteprednol etabonate
Rimexolone
Methylprednisolone
Clobetasol propionate
Fluocinonide
Prednicarbate
Fluoxymesterone
Budesonide
Dexamethasone
Desonide
Cortisone acetate
Paramethasone
Drospirenone
Ciclesonide
Hexane-1,6-Diol
Aldosterone
ORG-34517
Difluprednate
Ulipristal
Fluticasone furoate
Tixocortol
Difluocortolone
Gestrinone
Deflazacort
Onapristone
Cortivazol
Clobetasone
Fluticasone
Mometasone furoate
Hydrocortisone aceponate
Hydrocortisone acetate
Hydrocortisone butyrate
Hydrocortisone cypionate
Hydrocortisone phosphate
Hydrocortisone probutate
Hydrocortisone valerate
Segesterone acetate
Prednisolone phosphate
Dexamethasone acetate
Betamethasone phosphate
Prednisolone acetate
Diseases
46,XX disorders of sex development (Disorders related to androgen excess), including: Congenital adrenal hyperplasias; Glucocorticoid resistance; Aromatase deficiency
GWAS
Atrial fibrillation (
30061737
29892015
)
Lymphocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Night sleep phenotypes (
27126917
)
PR interval (
32439900
)
Spatial processing (
31596458
)
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
28240269
)
Inflammatory bowel disease (
28067908
)
Schizophrenia (
30285260
)
Ulcerative colitis (
28067908
)
Interacting Genes
160 interacting genes:
ABCC1
ADA
AR
ARPC5
BAG1
C1orf94
CALM1
CALR
CEBPA
CEBPB
CENPB
CHD9
COPS6
CREB1
CREBBP
DAP3
DAPK1
DCAF6
DDX54
DNMT3L
DOCK3
DTD1
ECD
EFHC2
EGFR
EPB41L1
ETS1
ETS2
FAM161B
FKBP4
FTH1
FYN
GNB1
GNB2
GRIP1
H3C1
HDAC1
HDAC6
HMGB1
HMGB2
HMOX2
HNRNPA1
HNRNPU
HSP90AA1
HSP90AB1
HSPA1A
HSPD1
IDE
IFNGR2
JUN
KAT5
KDM5A
KPNA2
KRTCAP3
LCK
LPXN
LRIF1
MAFF
MAPK1
MAPK15
MAPK8
MDM2
MED1
MED14
MED25
MSX2
NCL
NCOA1
NCOA2
NCOA3
NCOA4
NCOA6
NCOR1
NCOR2
NEDD4L
NFKB1
NFKB2
NR0B1
NR0B2
NR1H3
NR2E3
NR2F2
NR2F6
NR3C2
NR4A1
NRIP1
NUP54
ONECUT1
OSGEP
PBX1
PELP1
PIAS2
PML
POLR1D
POU1F1
POU2F1
POU2F2
PPARGC1A
PRDX3
PRKACA
PRKDC
PRPF6
PSMC3IP
PTGES3
PTMS
RACK1
RAD54L2
RAD9A
RAF1
RAN
RARA
RBM14
RELA
RFPL2
RNF14
RXRB
SFN
SGTA
SHKBP1
SLC25A4
SMAD3
SMARCA2
SMARCA4
SMARCB1
SMARCC1
SMARCD1
SMARCE1
SPIN2A
SRA1
SRC
STAT3
STAT5A
STAT5B
STRN3
STUB1
SUMO1
SUMO4
SVIL
SYT1
TADA2A
TBP
TDG
TGFB1I1
TMF1
TNS4
TP53
TRIM24
TRIM28
TSG101
TXN
UBB
UBE2I
UBE2L3
WTIP
YWHAH
ZBTB16
ZBTB20
ZBTB3
ZBTB9
ZNF496
88 interacting genes:
AIFM1
AIMP2
APAF1
APEX1
APOB
ATXN1
BAG1
BAG2
BAG3
BAG4
BCL2
BRSK1
CACNA1E
CDK9
CFAP52
DAPP1
DNAAF4
DNAJA2
DNAJA3
DNAJB1
DNAJB11
DNAJC3
EGFR
EIF2AK2
ERBB2
ERBB3
FANCC
FOS
GPR37
GRIN1
GRIN2D
HAP1
HCFC1
HEMGN
HIVEP1
HMGA1
HSBP1
HSF1
HSPA8
HSPBP1
IKBKG
INS
KRT18
KRT7
MAP3K5
MAPRE1
METTL21A
MOS
MSR1
NQO1
NR3C1
PEX5
PGR
PLG
POT1
PPP1R15A
PRKCA
PSMC5
PTGES3
PTMA
PTPRF
RAP1A
RAPGEF2
RHOA
SAE1
SLC13A1
SLC5A1
SNCB
SNRK
SOX9
ST13
STIP1
STUB1
SUMO2
TCERG1
TGM2
TOMM70
TP53
TRIAP1
TRIM24
TRIM38
TSSK6
TTC1
XIAP
YWHAB
YWHAG
YWHAQ
YWHAZ
Entrez ID
2908
3303
HPRD ID
00679
00774
Ensembl ID
ENSG00000113580
ENSG00000204389
Uniprot IDs
B7Z7I2
E5KQF5
E5KQF6
F1D8N4
P04150
A8K5I0
B3KTT5
P0DMV8
P0DMV9
PDB IDs
1M2Z
1NHZ
1P93
3BQD
3CLD
3E7C
3H52
3K22
3K23
4CSJ
4HN5
4HN6
4LSJ
4MDD
4P6W
4P6X
4UDC
4UDD
5CBX
5CBY
5CBZ
5CC1
5E69
5E6A
5E6B
5E6C
5E6D
5EMC
5EMP
5EMQ
5G3J
5G5W
5NFP
5NFT
5UC3
5VA0
5VA7
6BQU
6CFN
6DXK
6EL6
6EL7
6EL9
1HJO
1S3X
1XQS
2E88
2E8A
2LMG
3A8Y
3ATU
3ATV
3AY9
3D2E
3D2F
3JXU
3LOF
3Q49
4IO8
4J8F
4PO2
4WV5
4WV7
5AQW
5AQX
5AQY
5AQZ
5AR0
5BN8
5BN9
5BPL
5BPM
5BPN
5GJJ
5MKR
5MKS
5XI9
5XIR
6FDT
6FHK
6G3R
6G3S
6JPV
6K39
Enriched GO Terms of Interacting Partners
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