HSPB2 and MT-CO3

Data Source:
BioGRID (two hybrid)

		HSPB2	MT-CO3
Description		heat shock protein family B (small) member 2	cytochrome c oxidase subunit III
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane Respiratory Chain Complex IV
	Molecular Function	Structural Constituent Of Eye Lens Protein Binding Enzyme Activator Activity	Cytochrome-c Oxidase Activity Protein Binding Electron Transfer Activity Oxidoreduction-driven Active Transmembrane Transporter Activity
	Biological Process	Response To Unfolded Protein Regulation Of Catalytic Activity	Mitochondrial Electron Transport, Cytochrome C To Oxygen Respiratory Chain Complex IV Assembly Aerobic Respiration Proton Transmembrane Transport
Pathways			TP53 Regulates Metabolic Genes Respiratory electron transport
Drugs			Cholic Acid N-Formylmethionine
Diseases			Leber optic atrophy; Leber hereditary optic atrophy (LHON)
GWAS
Interacting Genes		108 interacting genes: A1CF A2M ABCC9 ABCD4 ACAA2 ACTA1 ACTB ACTC1 ACTG1 AGAP11 ALDH2 ALDOA ASAH1 ATP5F1A ATP6V1E1 B2M BAG3 BEX2 BEX4 BGN BICRAL C1QA CAPZA2 CEP19 CKM CLK4 CMYA5 CRYAA CRYAB CRYGC CTSB CTSD CYP1B1 DCTN1 DCTN6 DDIT4 DMPK DUSP1 EEF1A1 EIF4A2 ENKD1 ENO1 ENO3 ETFA FHL2 FLNC GAPDH GARS1 HADHB HNRNPD HOXB9 HSPB3 HSPB8 KANK2 LGALS1 LMO1 LMO3 MAPKAPK5 MB MCCC2 MDH1 MISP MLF2 MT-CO1 MT-CO2 MT-CO3 MYBPC3 MYH6 MYOM2 MYOZ2 NARS1 NDUFA13 NDUFA6 NT5DC2 PARVA PATZ1 PGM1 PKP2 POGZ PPM1K PRR35 RFPL3 RPL11 RPL36A RPL36AL RPS11 RPS6KA5 RYR2 SDF2 SDHA SLC2A1 SNCA SNU13 SNX18 TATDN1 TCAP THEMIS2 THUMPD2 TLX3 TNNI3 TTN TXNIP UBL5 VEZF1 WDR1 WWOX YPEL3 ZNF335	5 interacting genes: HSPB2 KRAS LIG4 RAC1 SNCA
Entrez ID		3316	4514
HPRD ID		03712	02471
Ensembl ID		ENSG00000170276	ENSG00000198938
Uniprot IDs		A8KAH6 Q16082	A0A1X7RBF0 P00414 Q7GIM7
PDB IDs		6F2R	5Z62
Enriched GO Terms of Interacting Partners?
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