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HRG and C1QB
Data Source:
HPRD
(in vivo)
HRG
C1QB
Description
histidine rich glycoprotein
complement C1q B chain
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Plasma Membrane
Cell Surface
Platelet Alpha Granule Lumen
Endolysosome
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Extracellular Region
Collagen Trimer
Complement Component C1 Complex
Synapse
Collagen-containing Extracellular Matrix
Blood Microparticle
Postsynapse
Molecular Function
Endopeptidase Inhibitor Activity
Serine-type Endopeptidase Inhibitor Activity
Cysteine-type Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Heparin Binding
Zinc Ion Binding
Immunoglobulin Binding
Heme Binding
Heparan Sulfate Proteoglycan Binding
Metal Ion Binding
Protein Binding
Biological Process
Angiogenesis
Platelet Degranulation
Positive Regulation Of Immune Response To Tumor Cell
Chemotaxis
Negative Regulation Of Cell Adhesion
Negative Regulation Of Cell Population Proliferation
Regulation Of Gene Expression
Regulation Of Platelet Activation
Negative Regulation Of Lamellipodium Assembly
Negative Regulation Of Endopeptidase Activity
Heme Transport
Negative Regulation Of Angiogenesis
Platelet Activation
Regulation Of Blood Coagulation
Negative Regulation Of Cell Growth
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of Cell Adhesion Mediated By Integrin
Fibrinolysis
Positive Regulation Of Apoptotic Process
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Fungus
Cytolysis By Host Of Symbiont Cells
Positive Regulation Of Focal Adhesion Assembly
Negative Regulation Of Fibrinolysis
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Positive Regulation Of Blood Vessel Remodeling
Negative Regulation Of Endothelial Cell Chemotaxis
Complement Activation
Complement Activation, Classical Pathway
Regulation Of Complement Activation
Innate Immune Response
Synapse Pruning
Pathways
Platelet degranulation
Dissolution of Fibrin Clot
Initial triggering of complement
Classical antibody-mediated complement activation
Regulation of Complement cascade
Drugs
Zinc chloride
Zinc sulfate, unspecified form
Cetuximab
Etanercept
Palivizumab
Daclizumab
Bevacizumab
Zinc
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
Inherited thrombophilia
Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS
Activated partial thromboplastin time (
22703881
20303064
)
Blood protein levels (
29875488
28240269
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Neurological blood protein biomarker levels (
31320639
)
Refractive error (
32231278
)
Interacting Genes
15 interacting genes:
C1QA
C1QB
CHRD
CYSRT1
FCGR1A
FGA
FN1
PLG
PLSCR1
RABAC1
RCHY1
RGS20
SPRY1
THBS1
TNFRSF1A
11 interacting genes:
C1QA
C1QC
C1R
DEFA1
EDA2R
HRG
IL32
MYOC
PTX3
RELA
UBQLN2
Entrez ID
3273
713
HPRD ID
00812
00394
Ensembl ID
ENSG00000113905
ENSG00000173369
Uniprot IDs
P04196
A0A024RAB9
P02746
PDB IDs
1PK6
2JG8
2JG9
2WNU
2WNV
5HKJ
5HZF
6FCZ
6Z6V
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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