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HRG and FCGR1A
Data Source:
HPRD
(in vivo)
HRG
FCGR1A
Description
histidine rich glycoprotein
Fc fragment of IgG receptor Ia
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Plasma Membrane
Cell Surface
Platelet Alpha Granule Lumen
Endolysosome
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Plasma Membrane
Integral Component Of Plasma Membrane
Clathrin-coated Endocytic Vesicle Membrane
Early Endosome Membrane
Molecular Function
Endopeptidase Inhibitor Activity
Serine-type Endopeptidase Inhibitor Activity
Cysteine-type Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Heparin Binding
Zinc Ion Binding
Immunoglobulin Binding
Heme Binding
Heparan Sulfate Proteoglycan Binding
Metal Ion Binding
Transmembrane Signaling Receptor Activity
Protein Binding
IgG Binding
Biological Process
Angiogenesis
Platelet Degranulation
Positive Regulation Of Immune Response To Tumor Cell
Chemotaxis
Negative Regulation Of Cell Adhesion
Negative Regulation Of Cell Population Proliferation
Regulation Of Gene Expression
Regulation Of Platelet Activation
Negative Regulation Of Lamellipodium Assembly
Negative Regulation Of Endopeptidase Activity
Heme Transport
Negative Regulation Of Angiogenesis
Platelet Activation
Regulation Of Blood Coagulation
Negative Regulation Of Cell Growth
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of Cell Adhesion Mediated By Integrin
Fibrinolysis
Positive Regulation Of Apoptotic Process
Regulation Of Protein-containing Complex Assembly
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Peptidyl-tyrosine Phosphorylation
Defense Response To Fungus
Cytolysis By Host Of Symbiont Cells
Positive Regulation Of Focal Adhesion Assembly
Negative Regulation Of Fibrinolysis
Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Positive Regulation Of Blood Vessel Remodeling
Negative Regulation Of Endothelial Cell Chemotaxis
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Receptor-mediated Endocytosis
Phagocytosis, Engulfment
Immune Response
Signal Transduction
Cell Surface Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of Immune Response
Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of Protein Tyrosine Kinase Activity
Pathways
Platelet degranulation
Dissolution of Fibrin Clot
Cross-presentation of soluble exogenous antigens (endosomes)
Cross-presentation of soluble exogenous antigens (endosomes)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
FCGR activation
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Interferon gamma signaling
FCGR3A-mediated IL10 synthesis
Drugs
Zinc chloride
Zinc sulfate, unspecified form
Cetuximab
Etanercept
Human immunoglobulin G
Gemtuzumab ozogamicin
Alemtuzumab
Natalizumab
Palivizumab
Daclizumab
Bevacizumab
Porfimer sodium
Catumaxomab
Sarilumab
Trastuzumab deruxtecan
Diseases
Inherited thrombophilia
GWAS
Activated partial thromboplastin time (
22703881
20303064
)
Blood protein levels (
29875488
28240269
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Neurological blood protein biomarker levels (
31320639
)
Refractive error (
32231278
)
Interacting Genes
15 interacting genes:
C1QA
C1QB
CHRD
CYSRT1
FCGR1A
FGA
FN1
PLG
PLSCR1
RABAC1
RCHY1
RGS20
SPRY1
THBS1
TNFRSF1A
30 interacting genes:
ADIPOQ
APCS
ASGR1
BIK
BMP10
CD163
CLDN19
CLEC7A
CRKL
CRP
FAM3C
FCAR
FCGR3A
HCK
HRG
ITM2A
JAGN1
LAT
LHFPL5
LILRB2
MALL
NINJ1
NRSN1
RPRM
SYK
TNMD
TSPO2
UPK2
VSTM1
VTI1B
Entrez ID
3273
2209
HPRD ID
00812
00904
Ensembl ID
ENSG00000113905
ENSG00000150337
Uniprot IDs
P04196
P12314
PDB IDs
3RJD
4W4O
4X4M
4ZNE
Enriched GO Terms of Interacting Partners
?
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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