HRG and FGA

Data Source:
HPRD (in vivo)

		HRG	FGA
Description		histidine rich glycoprotein	fibrinogen alpha chain
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Cell Surface Platelet Alpha Granule Lumen Endolysosome Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Fibrinogen Complex Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Synapse Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle Extracellular Vesicle
	Molecular Function	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Heparin Binding Zinc Ion Binding Immunoglobulin Binding Heme Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding	Signaling Receptor Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Angiogenesis Platelet Degranulation Positive Regulation Of Immune Response To Tumor Cell Chemotaxis Negative Regulation Of Cell Adhesion Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Regulation Of Platelet Activation Negative Regulation Of Lamellipodium Assembly Negative Regulation Of Endopeptidase Activity Heme Transport Negative Regulation Of Angiogenesis Platelet Activation Regulation Of Blood Coagulation Negative Regulation Of Cell Growth Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Cell Adhesion Mediated By Integrin Fibrinolysis Positive Regulation Of Apoptotic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Blood Vessel Endothelial Cell Migration Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Fungus Cytolysis By Host Of Symbiont Cells Positive Regulation Of Focal Adhesion Assembly Negative Regulation Of Fibrinolysis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Blood Vessel Remodeling Negative Regulation Of Endothelial Cell Chemotaxis	Toll-like Receptor Signaling Pathway Adaptive Immune Response Platelet Degranulation Cell-matrix Adhesion Blood Coagulation Extracellular Matrix Organization Plasminogen Activation Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein-containing Complex Assembly Fibrinolysis Induction Of Bacterial Agglutination Post-translational Protein Modification Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Protein-containing Complex Assembly Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Blood Coagulation, Common Pathway Blood Coagulation, Fibrin Clot Formation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Platelet degranulation Dissolution of Fibrin Clot	Platelet degranulation Common Pathway of Fibrin Clot Formation Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MAP2K and MAPK activation Regulation of TLR by endogenous ligand Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Post-translational protein phosphorylation Signaling downstream of RAS mutants Signaling by RAF1 mutants Amyloid fiber formation
Drugs		Zinc chloride Zinc sulfate, unspecified form	Alteplase Reteplase Anistreplase Tenecteplase Sucralfate Zinc Alfimeprase Ancrod EP-2104R Lanoteplase Thrombin Prothrombin Human thrombin Thrombin alfa Anti-inhibitor coagulant complex Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Inherited thrombophilia	Afibrinogenemia; Dysfibrinogenemia Inherited thrombophilia Familial amyloidosis
GWAS		Activated partial thromboplastin time ( 22703881 20303064) Blood protein levels ( 29875488 28240269) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Neurological blood protein biomarker levels ( 31320639) Refractive error ( 32231278)	D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Ischemic stroke ( 29531354) Stroke ( 29531354) Venous thromboembolism ( 21980494)
Interacting Genes		15 interacting genes: C1QA C1QB CHRD CYSRT1 FCGR1A FGA FN1 PLG PLSCR1 RABAC1 RCHY1 RGS20 SPRY1 THBS1 TNFRSF1A	27 interacting genes: AGTRAP APP CDH5 EXOC5 F13A1 F2 FGB FGG HRG ITGA2B ITGB3 MEOX2 NID1 PLAT PRRC2A SERPINA5 SERPINF2 SH3BP1 STX1B STX2 SYCE1L TFIP11 THBS1 TMEM43 TPM1 TPM3 UBC
Entrez ID		3273	2243
HPRD ID		00812	00619
Ensembl ID		ENSG00000113905	ENSG00000171560
Uniprot IDs		P04196	P02671
PDB IDs			1BBR 1DM4 1FPH 1FZA 1FZB 1FZC 1FZD 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 1YCP 2A45 2FFD 2H43 2HLO 2HOD 2HPC 2OYH 2OYI 2Q9I 2XNX 2XNY 2Z4E 3AT0 3BVH 3E1I 3GHG 3H32 3HUS 4F27 5CFA
Enriched GO Terms of Interacting Partners?
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