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H3-3A and SUV39H1
Data Source:
BioGRID
(enzymatic study)
H3-3A
SUV39H1
Description
H3.3 histone A
suppressor of variegation 3-9 homolog 1
Image
GO Annotations
Cellular Component
Nuclear Chromosome
Chromosome, Telomeric Region
Nucleosome
Barr Body
Extracellular Region
Nucleus
Nucleoplasm
Protein-containing Complex
Extracellular Exosome
Chromosome, Centromeric Region
Heterochromatin
Condensed Nuclear Chromosome
Nucleus
Nuclear Lamina
Nucleoplasm
Chromatin Silencing Complex
RDNA Heterochromatin
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
Protein Binding
Nucleosomal DNA Binding
Protein Heterodimerization Activity
Transcription Regulatory Region Sequence-specific DNA Binding
Chromatin Binding
Protein Binding
Zinc Ion Binding
S-adenosylmethionine-dependent Methyltransferase Activity
Histone-lysine N-methyltransferase Activity
Histone Methyltransferase Activity
Histone Methyltransferase Activity (H3-K9 Specific)
Protein N-terminus Binding
Biological Process
RDNA Heterochromatin Assembly
Osteoblast Differentiation
Nucleosome Assembly
DNA Replication-independent Nucleosome Assembly
Nucleus Organization
Spermatid Development
Single Fertilization
Embryo Implantation
Blood Coagulation
Cell Population Proliferation
Male Gonad Development
Positive Regulation Of Cell Growth
Pericentric Heterochromatin Assembly
Subtelomeric Heterochromatin Assembly
Telomere Organization
Multicellular Organism Growth
Muscle Cell Differentiation
Cellular Protein Metabolic Process
Regulation Of Megakaryocyte Differentiation
Negative Regulation Of Gene Expression, Epigenetic
Oogenesis
Regulation Of Gene Silencing By MiRNA
Regulation Of Centromere Complex Assembly
Negative Regulation Of Chromosome Condensation
Negative Regulation Of Transcription By RNA Polymerase II
RDNA Heterochromatin Assembly
Chromatin Organization
RRNA Processing
Cellular Response To DNA Damage Stimulus
Cell Cycle
Viral Process
Cell Differentiation
Histone Lysine Methylation
Histone H3-K9 Dimethylation
Histone H3-K9 Trimethylation
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Transcription, DNA-templated
Rhythmic Process
Cellular Response To Hypoxia
Pathways
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Factors involved in megakaryocyte development and platelet production
PKMTs methylate histone lysines
SIRT1 negatively regulates rRNA expression
Drugs
Diseases
GWAS
Interacting Genes
38 interacting genes:
ASF1A
ASF1B
ATRX
BPTF
BRD7
CARM1
CHD1
CREBBP
DAXX
DCAF1
EP300
ESR1
HMGB2
HPF1
KAT2B
KMT2A
MAPK9
NEDD4
NOS3
PARP1
PARP10
PARP2
PELP1
PIM1
PPM1D
PPP1CA
PPP1CB
SET
SETD7
SMARCA1
SMARCA4
SMARCA5
SS18
SSRP1
SUPT16H
SUV39H1
TLE2
ZMYND11
138 interacting genes:
ATE1
ATF3
ATP6V1B1
BAHD1
BCL11B
C4orf17
C8orf74
CBX1
CBX3
CBX4
CBX5
CDC23
CDCA4
CDCA7L
CEP70
CFAP100
CLK3
CRBN
CREBBP
CRELD2
DBF4B
DCAF8
DDB1
DNMT1
DNMT3A
DNMT3B
DVL3
ELOF1
EP300
ESR1
EZH2
FGD5
FOXR2
FRMD6
FUS
FYN
GOLGA6L9
GPATCH2L
GTF2H2C_2
GTPBP2
H3-3A
H3-4
H3-5
H3C1
H3C15
HDAC1
HDAC2
HDAC3
HDAC5
HOOK2
HOXA1
HOXC4
ID1
ID2
IGFBP4
IL16
ING4
INTS2
KDM1A
KLF15
KLHDC4
KLHL20
KRTAP10-7
KRTAP10-8
LDHAL6B
LENG8
LHX8
LINC02875
LNX1
LOXL4
LZTS2
MALT1
MBD1
MBD4
MCRS1
MSANTD3
MTF2
MTO1
MYOD1
NR1H2
NR1H3
ODAD3
OPA3
PADI6
PHF19
PML
PNKP
PPP1R16A
PRIM2
PRMT6
PSMC1
RASSF1
RASSF2
RB1
RBBP4
RBBP7
RBL1
RBL2
RIN3
RRP8
RSPO2
RUNX1
SBF1
SLFN12
SMAD1
SMAD5
SPATA24
SPRED1
SPSB1
SRGAP3
STX11
STX19
TEKT4
TEX35
THRA
TMEM11
TNFAIP1
TNS2
TRIM41
U2AF1
WDFY3
WIZ
ZBTB2
ZBTB24
ZCCHC17
ZKSCAN5
ZNF165
ZNF417
ZNF436
ZNF438
ZNF451
ZNF557
ZNF581
ZNF649
ZNF670
ZNF829
ZRANB1
ZSCAN9
Entrez ID
3020
6839
HPRD ID
03082
02221
Ensembl ID
ENSG00000163041
ENSG00000101945
Uniprot IDs
B2R4P9
P84243
O43463
PDB IDs
2L43
3ASK
3ASL
3AV2
3JVK
3MUK
3MUL
3QL9
3QLA
3QLC
3WTP
4GNE
4GNF
4GNG
4GU0
4GUR
4GUS
4GY5
4H9N
4H9O
4H9P
4H9Q
4H9R
4H9S
4HGA
4L58
4N4I
4O62
4QQ4
4TMP
4U7T
4W5A
5B32
5B33
5BNV
5BNX
5DWQ
5DX0
5JA4
5JJY
5JLB
5KDM
5X7X
6A5L
6A5O
6A5P
6A5R
6A5T
6A5U
6HGT
6INQ
6IR9
6J4W
6J4X
6J4Y
6J4Z
6J50
6J51
6J9J
6PZV
6QXZ
6R0C
6RNY
6U04
7A08
3MTS
Enriched GO Terms of Interacting Partners
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