H3-3A and PARP2

Data Source:
BioGRID (enzymatic study)

		H3-3A	PARP2
Description		H3.3 histone A	poly(ADP-ribose) polymerase 2
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GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nucleosome Barr Body Extracellular Region Nucleus Nucleoplasm Protein-containing Complex Extracellular Exosome	Nucleoplasm Nucleolus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Protein Binding Nucleosomal DNA Binding Protein Heterodimerization Activity	DNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding NAD DNA ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity
	Biological Process	RDNA Heterochromatin Assembly Osteoblast Differentiation Nucleosome Assembly DNA Replication-independent Nucleosome Assembly Nucleus Organization Spermatid Development Single Fertilization Embryo Implantation Blood Coagulation Cell Population Proliferation Male Gonad Development Positive Regulation Of Cell Growth Pericentric Heterochromatin Assembly Subtelomeric Heterochromatin Assembly Telomere Organization Multicellular Organism Growth Muscle Cell Differentiation Cellular Protein Metabolic Process Regulation Of Megakaryocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Oogenesis Regulation Of Gene Silencing By MiRNA Regulation Of Centromere Complex Assembly Negative Regulation Of Chromosome Condensation	DNA Repair Base-excision Repair Double-strand Break Repair Protein ADP-ribosylation Peptidyl-serine ADP-ribosylation DNA ADP-ribosylation Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Protein Poly-ADP-ribosylation Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Death
Pathways		Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Amyloid fiber formation Factors involved in megakaryocyte development and platelet production	POLB-Dependent Long Patch Base Excision Repair HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER
Drugs			Veliparib Olaparib Talazoparib Niraparib Rucaparib
Diseases
GWAS			Menopause (age at onset) ( 26414677)
Interacting Genes		38 interacting genes: ASF1A ASF1B ATRX BPTF BRD7 CARM1 CHD1 CREBBP DAXX DCAF1 EP300 ESR1 HMGB2 HPF1 KAT2B KMT2A MAPK9 NEDD4 NOS3 PARP1 PARP10 PARP2 PELP1 PIM1 PPM1D PPP1CA PPP1CB SET SETD7 SMARCA1 SMARCA4 SMARCA5 SS18 SSRP1 SUPT16H SUV39H1 TLE2 ZMYND11	13 interacting genes: BUB3 CASP8 CENPA CENPB H1-0 H1-5 H2BC4 H3-3A H3-4 H3C1 HPF1 PARP1 XRCC1
Entrez ID		3020	10038
HPRD ID		03082	09660
Ensembl ID		ENSG00000163041	ENSG00000129484
Uniprot IDs		B2R4P9 P84243	Q9UGN5
PDB IDs		2L43 3ASK 3ASL 3AV2 3JVK 3MUK 3MUL 3QL9 3QLA 3QLC 3WTP 4GNE 4GNF 4GNG 4GU0 4GUR 4GUS 4GY5 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4L58 4N4I 4O62 4QQ4 4TMP 4U7T 4W5A 5B32 5B33 5BNV 5BNX 5DWQ 5DX0 5JA4 5JJY 5JLB 5KDM 5X7X 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6HGT 6INQ 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6J9J 6PZV 6QXZ 6R0C 6RNY 6U04 7A08	3KCZ 3KJD 4PJV 4TVJ 4ZZX 4ZZY 5D5K 5DSY 6F1K 6F5B 6F5F 6TX3 6USJ 6X0L 6X0M 6X0N
Enriched GO Terms of Interacting Partners?
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