GUCY2D and GUCA1A

Data Source:
HPRD (in vitro)

		GUCY2D	GUCA1A
Description		guanylate cyclase 2D, retinal	guanylate cyclase activator 1A
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Nuclear Outer Membrane Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Photoreceptor Outer Segment Membrane Photoreceptor Disc Membrane	Photoreceptor Inner Segment Photoreceptor Disc Membrane Cone Photoreceptor Outer Segment
	Molecular Function	Peptide Receptor Activity Guanylate Cyclase Activity Protein Kinase Activity Protein Binding ATP Binding GTP Binding Signaling Receptor Activity Protein Homodimerization Activity	Calcium Ion Binding Protein Binding Calcium Sensitive Guanylate Cyclase Activator Activity Guanylate Cyclase Regulator Activity
	Biological Process	CGMP Biosynthetic Process Protein Phosphorylation Signal Transduction Receptor Guanylyl Cyclase Signaling Pathway Visual Perception Regulation Of Rhodopsin Mediated Signaling Pathway Intracellular Signal Transduction	Signal Transduction Visual Perception Phototransduction Positive Regulation Of CGMP-mediated Signaling Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Guanylate Cyclase Activity Cellular Response To Calcium Ion
Pathways		Inactivation, recovery and regulation of the phototransduction cascade	Inactivation, recovery and regulation of the phototransduction cascade
Drugs			Myristic acid
Diseases		Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)	Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Refractive error ( 32231278)	Spatial processing ( 31596458)
Interacting Genes		5 interacting genes: GUCA1A GUCA1B GUCA2B RGS9 S100B	9 interacting genes: AGR2 C1QTNF5 DDIT4L DEFB118 GSC2 GUCY2D HSPB1 KATNAL1 PRKAR1B
Entrez ID		3000	2978
HPRD ID		02550	02648
Ensembl ID		ENSG00000132518	ENSG00000048545
Uniprot IDs		Q02846	B2R9P6 P43080
PDB IDs		1AWL
Enriched GO Terms of Interacting Partners?
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