RPA4 and XPA

Data Source:
HPRD (in vitro, two hybrid)

		RPA4	XPA
Description		replication protein A4	XPA, DNA damage recognition and repair factor
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break	Nucleotide-excision Repair Factor 1 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Intercellular Bridge
	Molecular Function	Single-stranded DNA Binding Protein Binding	Damaged DNA Binding Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Replication Initiation Nucleotide-excision Repair Nuclear DNA Replication	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion UV Protection Response To Auditory Stimulus Nucleotide-excision Repair, DNA Incision Protein Localization To Nucleus Global Genome Nucleotide-excision Repair UV-damage Excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways		Activation of the pre-replicative complex	Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS			Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Serum thyroid-stimulating hormone levels ( 24852370) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Interacting Genes		8 interacting genes: APP MSH2 MSH3 MUTYH PTRHD1 RPA1 RPA3 XPA	51 interacting genes: ARID3A ATM ATR AURKA BMPR1A BUB1 DDB1 DDB2 DLC1 DVL3 ERCC1 ERCC4 ERCC6 FBXW7 GPN1 GTF2E2 GTF2H1 HERC2 MEOX2 MLH1 MLH3 MSH2 MSH3 MUTYH NDEL1 NRAS PCNA PDGFRL PICK1 PMS2 POLR1C PRDM16 PRKDC PSMB1 RASSF1 RB1 RHOU RPA1 RPA2 RPA4 SKIL SMAD2 SNPH SRC STK11 TBC1D7 TRIM27 VPS26C XAB2 XPC ZNF655
Entrez ID		29935	7507
HPRD ID		06591	02045
Ensembl ID		ENSG00000204086	ENSG00000136936
Uniprot IDs		Q13156	P23025
PDB IDs			1D4U 1XPA 2JNW 6J44 6LAE 6RO4
Enriched GO Terms of Interacting Partners?
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