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XPA and PCNA
Data Source:
BioGRID
(affinity chromatography technology, fluorescent resonance energy transfer)
XPA
PCNA
Description
XPA, DNA damage recognition and repair factor
proliferating cell nuclear antigen
Image
GO Annotations
Cellular Component
Nucleotide-excision Repair Factor 1 Complex
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
Cytoplasm
Intercellular Bridge
Cyclin-dependent Protein Kinase Holoenzyme Complex
Chromosome, Telomeric Region
Chromatin
Nucleus
Nuclear Lamina
Nucleoplasm
Replication Fork
Centrosome
Nuclear Body
Replisome
Nuclear Replication Fork
PCNA Complex
Extracellular Exosome
PCNA-p21 Complex
Molecular Function
Damaged DNA Binding
Protein Binding
Protein Domain Specific Binding
Protein Homodimerization Activity
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Purine-specific Mismatch Base Pair DNA N-glycosylase Activity
Chromatin Binding
Damaged DNA Binding
Protein Binding
Protein C-terminus Binding
Enzyme Binding
Estrogen Receptor Binding
DNA Polymerase Processivity Factor Activity
Receptor Tyrosine Kinase Binding
Dinucleotide Insertion Or Deletion Binding
MutLalpha Complex Binding
Histone Acetyltransferase Binding
Identical Protein Binding
Protein-containing Complex Binding
DNA Polymerase Binding
Biological Process
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Duplex Unwinding
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
UV Protection
Response To Auditory Stimulus
Nucleotide-excision Repair, DNA Incision
Protein Localization To Nucleus
Global Genome Nucleotide-excision Repair
UV-damage Excision Repair
Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Telomere Maintenance
Leading Strand Elongation
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair, Gap-filling
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Heart Development
Viral Process
Protein Ubiquitination
Translesion Synthesis
Epithelial Cell Differentiation
Replication Fork Processing
Positive Regulation Of Deoxyribonuclease Activity
Telomere Maintenance Via Semi-conservative Replication
Response To Estradiol
Nucleotide-excision Repair, DNA Incision
Cellular Response To UV
Error-prone Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Estrous Cycle
Positive Regulation Of DNA Repair
Positive Regulation Of DNA Replication
Response To Cadmium Ion
Cellular Response To Hydrogen Peroxide
Error-free Translesion Synthesis
Cellular Response To Xenobiotic Stimulus
Response To Dexamethasone
Liver Regeneration
Positive Regulation Of DNA-directed DNA Polymerase Activity
Response To L-glutamate
Mitotic Telomere Maintenance Via Semi-conservative Replication
Pathways
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Dual incision in TC-NER
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Transcription of E2F targets under negative control by DREAM complex
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Removal of the Flap Intermediate from the C-strand
SUMOylation of DNA replication proteins
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Homologous Recombination (HRR)
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Polymerase switching
Removal of the Flap Intermediate
Processive synthesis on the lagging strand
G1/S-Specific Transcription
E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Liothyronine
Acetylsalicylic acid
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS
Hypothyroidism (
27182965
)
Obesity-related traits (
23251661
)
Serum thyroid-stimulating hormone levels (
24852370
)
Thyroid cancer (Papillary, radiation-related) (
20350937
)
Interacting Genes
51 interacting genes:
ARID3A
ATM
ATR
AURKA
BMPR1A
BUB1
DDB1
DDB2
DLC1
DVL3
ERCC1
ERCC4
ERCC6
FBXW7
GPN1
GTF2E2
GTF2H1
HERC2
MEOX2
MLH1
MLH3
MSH2
MSH3
MUTYH
NDEL1
NRAS
PCNA
PDGFRL
PICK1
PMS2
POLR1C
PRDM16
PRKDC
PSMB1
RASSF1
RB1
RHOU
RPA1
RPA2
RPA4
SKIL
SMAD2
SNPH
SRC
STK11
TBC1D7
TRIM27
VPS26C
XAB2
XPC
ZNF655
139 interacting genes:
ALDOA
APEX1
APEX2
ATAD5
BAZ1B
CBX1
CCNB1
CCND1
CCND3
CCNO
CDC25C
CDC6
CDK1
CDK2
CDK5
CDK6
CDKN1A
CDKN1C
CDKN2A
CDT1
CHAF1A
CHTF18
CHTF8
CMTM5
CREBBP
DHX9
DNMT1
DNTT
DNTTIP2
DSCC1
DTL
EGFR
ENO1
EP300
ERCC5
ERCC6
ERRFI1
ESCO2
EXO1
FAN1
FANCD2
FANCL
FEN1
GADD45A
GADD45B
GADD45G
GAPDH
GCK
GPI
HDAC1
HUS1
HUWE1
IGF1R
ING1
KCTD13
KMT5A
LDHA
LIG1
LMNA
MCL1
MGMT
MLH1
MSH2
MSH3
MSH6
MUTYH
MYBBP1A
NMRAL1
NSD2
NTHL1
NUTF2
PARP1
PARP10
PARPBP
PCLAF
PFKM
PGAM1
PGK1
PKLR
PMS2
POLB
POLD1
POLD2
POLD3
POLD4
POLDIP2
POLE
POLH
POLI
POLK
POLL
POLM
PPP1CA
PRKDC
PTEN
PTMA
RAD18
RAD9A
RBBP8
RFC1
RFC2
RFC3
RFC4
RFC5
RFWD3
RNF8
RPA1
SDE2
SEC23IP
SIVA1
SLC30A8
SMARCAD1
SPG21
SUB1
SUMO1
TCOF1
TDG
TIRAP
TMEM218
TPI1
TRIM28
UBB
UBE2A
UBE2B
UBE2D3
UHRF1
UNG
USP1
USP2
USP4
WDR48
WRN
WRNIP1
XPA
XRCC1
XRCC5
XRCC6
YBX1
ZBTB1
Entrez ID
7507
5111
HPRD ID
02045
01456
Ensembl ID
ENSG00000136936
ENSG00000132646
Uniprot IDs
P23025
P12004
PDB IDs
1D4U
1XPA
2JNW
6J44
6LAE
6RO4
1AXC
1U76
1U7B
1UL1
1VYJ
1VYM
1W60
2ZVK
2ZVL
2ZVM
3JA9
3P87
3TBL
3VKX
3WGW
4D2G
4RJF
4ZTD
5E0T
5E0U
5E0V
5IY4
5MAV
5MLO
5MLW
5MOM
5YCO
5YD8
6CBI
6EHT
6FCM
6FCN
6GIS
6GWS
6HVO
6K3A
6QC0
6QCG
6S1M
6S1N
6S1O
6TNY
6TNZ
6VVO
Enriched GO Terms of Interacting Partners
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