RPA4 and MSH3

Data Source:
BioGRID (pull down)

		RPA4	MSH3
Description		replication protein A4	mutS homolog 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm DNA Replication Factor A Complex Site Of Double-strand Break	Nucleus Nucleoplasm Membrane Mismatch Repair Complex MutSbeta Complex
	Molecular Function	Single-stranded DNA Binding Protein Binding	Single-stranded DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Enzyme Binding Mismatched DNA Binding DNA Insertion Or Deletion Binding Guanine/thymine Mispair Binding Dinucleotide Insertion Or Deletion Binding Single Guanine Insertion Binding Dinucleotide Repeat Insertion Binding Oxidized Purine DNA Binding Protein Homodimerization Activity
	Biological Process	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Replication Initiation Nucleotide-excision Repair Nuclear DNA Replication	Meiotic Mismatch Repair Removal Of Nonhomologous Ends DNA Repair Mismatch Repair Mitotic Recombination Reciprocal Meiotic Recombination Somatic Recombination Of Immunoglobulin Gene Segments Replication Fork Arrest Maintenance Of DNA Repeat Elements Negative Regulation Of DNA Recombination Positive Regulation Of Helicase Activity
Pathways		Activation of the pre-replicative complex	Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Defective Mismatch Repair Associated With MSH3 Defective Mismatch Repair Associated With MSH2
Drugs
Diseases			Colorectal cancer
GWAS			Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) HDL cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Huntington's disease progression ( 28642124) Idiopathic downbeat nystagmus ( 32157568) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		8 interacting genes: APP MSH2 MSH3 MUTYH PTRHD1 RPA1 RPA3 XPA	14 interacting genes: BARD1 BRCA1 EXO1 HUS1 MLH1 MSH2 PCNA RAD1 RAD9A RCHY1 RPA4 SUMO2 TSC22D2 XPA
Entrez ID		29935	4437
HPRD ID		06591	02931
Ensembl ID		ENSG00000204086	ENSG00000113318
Uniprot IDs		Q13156	P20585
PDB IDs			3THW 3THX 3THY 3THZ
Enriched GO Terms of Interacting Partners?
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