GRIK2 and LIN7B

Data Source:
HPRD (in vitro, in vivo)

		GRIK2	LIN7B
Description		glutamate ionotropic receptor kainate type subunit 2	lin-7 homolog B, crumbs cell polarity complex component
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Postsynaptic Density Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Terminal Bouton Perikaryon Postsynaptic Membrane Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basolateral Plasma Membrane Synapse MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane
	Molecular Function	Extracellularly Glutamate-gated Ion Channel Activity Glutamate Receptor Activity Ligand-gated Ion Channel Activity Kainate Selective Glutamate Receptor Activity PDZ Domain Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Identical Protein Binding Ligand-gated Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential	Protein Binding Protein Domain Specific Binding PDZ Domain Binding L27 Domain Binding
	Biological Process	Behavioral Fear Response Cellular Calcium Ion Homeostasis Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Neuronal Action Potential Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of JNK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Neuron Apoptotic Process Negative Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Regulation Of Presynaptic Membrane Potential Detection Of Cold Stimulus Involved In Thermoception	Exocytosis Neurotransmitter Secretion Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Basolateral Plasma Membrane
Pathways		Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor	Dopamine Neurotransmitter Release Cycle RHO GTPases Activate Rhotekin and Rhophilins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs		Glutamic acid Butabarbital Butalbital Topiramate Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Phenobarbital Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Domoic Acid Quisqualic acid 2s,4r-4-Methylglutamate
Diseases		Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Biochemical measures ( 19260141) Cardiac hypertrophy ( 21348951) Emphysema imaging phenotypes ( 26030696) Heart rate response to recovery post exercise (20 sec) ( 29497042) Longevity (90 years and older) ( 25199915) Obesity-related traits ( 23251661) Obsessive-compulsive disorder ( 22889921) Palmitic acid (16:0) levels ( 23362303) Pursuit maintenance gain ( 29064472) Renal function-related traits (eGRFcrea) ( 22797727) Weight ( 28552196)
Interacting Genes		18 interacting genes: CALCOCO1 CASK CDH2 CTNNB1 CTNND1 DLG1 DLG3 DLG4 GRIA1 GRID2 GRIK4 GRIK5 GRIP1 LIN7B PICK1 PRKAA1 SDCBP TRIM25	22 interacting genes: ABCA1 APBA1 ASIC3 BAIAP2 CASK DLG4 ENKD1 GNG13 GRIK2 GRIN2B KCNJ12 KCNJ4 MAK16 MPP2 MPP3 MPP7 NTAQ1 PALS1 PALS2 PSMB1 TCEANC TRAPPC12
Entrez ID		2898	64130
HPRD ID		00692	10040
Ensembl ID		ENSG00000164418	ENSG00000104863
Uniprot IDs		A8K0H7 Q13002 Q8IY40	Q9HAP6
PDB IDs		3QXM 5CMM	2DKR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?