GRB14 and TRIM55

Data Source:
BioGRID (two hybrid)

		GRB14	TRIM55
Description		growth factor receptor bound protein 14	tripartite motif containing 55
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Endosome Membrane Intracellular Membrane-bounded Organelle	Nucleus Cytoplasm Microtubule
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding	Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Signal Transduction Insulin Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Leukocyte Migration	Leukocyte Migration Involved In Inflammatory Response Signal Transduction Protein Ubiquitination Diapedesis Macrophage Migration
Pathways		Tie2 Signaling
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Blood pressure ( 24954895 21572416) Body fat percentage ( 26833246 31453325) Body fat percentage variance ( 31453325) Body mass index ( 29381148 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Coronary artery disease ( 32469254 33020668) Diastolic blood pressure ( 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Fasting blood insulin ( 25631608) Fasting blood insulin (BMI interaction) ( 22581228) Glomerular filtration rate in chronic kidney disease ( 26420894) Glycine levels ( 30837465) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Hypertension ( 30487518) Immunoglobulin A vasculitis ( 28698626) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Mean arterial pressure ( 29403010 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Number of sexual partners ( 30643258) Perceived sweetness of sucrose ( 31005972) Pulse pressure ( 27841878 28739976 30487518) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to statin therapy ( 20339536) Sexual dimorphism in anthropometric traits ( 23754948) Systolic blood pressure ( 26390057 28135244 27841878 29403010 28739976 27618447 27618452) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Triglyceride levels ( 32203549 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Type 2 diabetes ( 22885922 24509480 21874001 30297969 29632382 32499647 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500) Waist-hip ratio ( 25673412 20935629) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in inactive individuals ( 28448500) Waist-to-hip ratio adjusted for BMI in non-smokers ( 28443625) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	Coronary heart disease event reduction (statin therapy interaction) ( 22666496) Metabolite levels ( 23823483) Recurrent major depressive disorder ( 29317602)
Interacting Genes		25 interacting genes: CDC5L CHFR DAPK3 EGFR ERBB2 FGFR1 FRS3 GIGYF1 GIGYF2 GOLGA2 HCK IGF1R INSR IRS1 MAP3K14 MET PDGFRA PDGFRB PRKCZ SQSTM1 STK26 TEK TNKS2 TRIM27 TRIM55	310 interacting genes: ACBD4 ACD ACTA1 ADAMTSL4 AEBP2 AFM AGO2 AKR1C8P ALKBH3 ANKRD1 ANKRD39 APLN APOBEC4 ARL6IP4 ATG4D ATP5F1B ATP5F1D ATXN3 ATXN3L ATXN7L1 BCAT1 BCHE BRAP BRD4 BRWD1 BTBD9 BYSL C10orf88 C12orf4 C1orf35 C3orf36 C8orf74 CADPS CAMK2A CAPN3 CARS1 CBX2 CCDC120 CCDC130 CCDC28B CDK3 CDS2 CENPK CHMP7 CKM COA7 COX4I1 CRCT1 CTAG1A CTAG1B CTNNB1 CTSF CYB5R2 CYP46A1 CYTOR DAPL1 DCAF11 DCAF6 DCTN3 DECR2 DEF8 DEK DES DNTTIP1 DOCK7 DYNLT2B EED EEF1G EHHADH EIF3E ELAPOR1 EPS8L2 ESPL1 EZH2 FAM185A FAM90A1 FANK1 FASTKD1 FHL2 FKBP6 FLNA FLNB FLNC FRMD6 FYN GABPB1 GATA3 GFM1 GLI4 GMEB1 GOLGA2P5 GPRIN2 GPS1 GRB10 GRB14 HID1 HIRA HOXA1 HROB HSPB1 ID1 IFI35 IGF2 IK IL37 ILF3 INCA1 ING4 INKA1 IQUB IRF2 IRF3 ITGB5 JADE3 KBTBD4 KCTD15 KIAA0087 KIAA0408 KIF13A KIF1B KIF5A KLHDC4 KLHL36 KMT2B KYAT1 LAGE3 LAMTOR5 LAPTM4A LIMS2 LINC00518 LINC00663 LINC00905 LINC01588 LMCD1 LMO2 LRRC56 LYN LYNX1 MAGEC3 MALSU1 MAP3K14 MBD4 MBIP MCM7 MDM4 MIDN MIIP MKI67 MLH3 MLLT11 MPP1 MPZL1 MRPL19 MRPL20-AS1 MRPL41 MSRB3 MYBPC1 MYBPC3 MYBPHL MYC MYCT1 MYOT MYOZ1 NDUFA1 NDUFA8 NEB NEBL NEFL NGEF NOMO1 NR1D2 NR2C2 NSD3 NSUN7 NUFIP2 ODF2 OGFOD2 OTUB1 OTUB2 P3H3 PACRGL PAFAH1B2 PCGF1 PCGF3 PCGF6 PELI3 PELO PHC2 PHF23 PIAS1 PIAS2 PIAS3 PIP4K2B PKM PLEKHG4 PLXNA3 POLD1 POLR2E PPARA PPIE PRKAB2 PRKACA PRR30 PRRT1 PYGM RABEPK RAD23A RAI2 RBM14 RELA REX1BD RGR RHEB RHPN1 RING1 RNF10 RNF114 RPS4X RRAS RUSC1 RUSC1-AS1 SEC23B SET SHFL SLC6A13 SLFN12 SNW1 SPATS1 SPRYD7 SPSB1 SPSB2 SQSTM1 STAM SYMPK SYNCRIP TCAP TCP10L TEX19 THAP3 TIGD5 TIMM17B TMBIM1 TMEM35A TNIP3 TNNI1 TNNI2 TNNI3 TOR1AIP2 TPD52L3 TRAF3IP2 TRIB3 TRIM23 TRIM27 TRIM35 TRIM41 TRIM54 TRIM63 TRIM69 TRMT10B TSC2 TSC22D4 TTN TUBGCP4 UBA3 UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2L3 UCHL3 UCHL5 UNKL USP13 USP28 USP4 USP5 USP7 USP8 UXT VAC14 VPS37A WT1 XAGE1B YOD1 YPEL3 ZBTB14 ZBTB17 ZC2HC1C ZC3H12A ZC3HC1 ZFYVE19 ZNF124 ZNF20 ZNF302 ZNF333 ZNF345 ZNF431 ZNF436 ZNF460 ZNF566 ZNF57 ZNF581 ZNF597 ZNF649 ZNF653 ZNF667-AS1 ZNF767P ZNF775 ZNF83 ZSCAN16
Entrez ID		2888	84675
HPRD ID		03313	05927
Ensembl ID		ENSG00000115290	ENSG00000147573
Uniprot IDs		Q14449	Q9BYV6
PDB IDs		2AUG 2AUH 4K81
Enriched GO Terms of Interacting Partners?
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