TSEN54 and LHX4

Data Source:
BioGRID (two hybrid)

		TSEN54	LHX4
Description		tRNA splicing endonuclease subunit 54	LIM homeobox 4
Image		No pdb structure
GO Annotations	Cellular Component	TRNA-intron Endonuclease Complex Nucleoplasm Nucleolus	Chromatin Nucleus
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	TRNA-type Intron Splice Site Recognition And Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing	Placenta Development Regulation Of Transcription By RNA Polymerase II Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		tRNA processing in the nucleus	Regulation of expression of SLITs and ROBOs
Drugs
Diseases		Pontocerebellar hypoplasia	Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Deep white matter hyperintensities ( 32517579) FEV1 ( 30804560) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Platelet count ( 32888494) Plateletcrit ( 32888494) Sight-threatening diabetic retinopathy in type 2 diabetes ( 26188370)	Refractive error ( 32231278)
Interacting Genes		21 interacting genes: BRCA1 CCDC57 CLP1 CSNK2B GOLGA6L9 IRF4 KPNA5 KRT31 LHX3 LHX4 LMO2 MCPH1 MRPL38 NAA10 NCKIPSD NFKBID RINT1 TRIM23 TRIML2 TSEN2 ZMYND12	53 interacting genes: ADAMTSL4 ARL2 AXIN1 BANP BOD1L2 CDK3 CENPS-CORT CHCHD2 CORO1B DCAF10 DHRS1 DNAJB13 ERO1A FDX2 GOLGA2 HOXC5 IFT172 IKZF1 INO80B KLHL38 KRT38 KRT40 LDB1 LDB2 LONRF1 MAPRE3 MRS2 MYOZ1 NRF1 ORC6 PARP11 POU1F1 QRICH1 SCAND1 SH2D1A SNRNP25 SNRPA SSX1 TCAP TCF4 TP53BP2 TRAPPC6A TRMT11 TSEN54 TSTD2 TXNDC5 UBQLN1 USP2 WASHC3 YY1 ZBTB2 ZNF354C ZNF76
Entrez ID		283989	89884
HPRD ID		12291	03686
Ensembl ID		ENSG00000182173	ENSG00000121454
Uniprot IDs		Q7Z6J9	A0A0S2Z5S4 Q969G2
PDB IDs			5HOD
Enriched GO Terms of Interacting Partners?
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