TSEN54 and KPNA5

Data Source:
BioGRID (two hybrid)

		TSEN54	KPNA5
Description		tRNA splicing endonuclease subunit 54	karyopherin subunit alpha 5
Image		No pdb structure
GO Annotations	Cellular Component	TRNA-intron Endonuclease Complex Nucleoplasm Nucleolus	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity
	Biological Process	TRNA-type Intron Splice Site Recognition And Cleavage TRNA Splicing, Via Endonucleolytic Cleavage And Ligation MRNA Processing	NLS-bearing Protein Import Into Nucleus Modulation By Virus Of Host Cellular Process
Pathways		tRNA processing in the nucleus	ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways
Drugs
Diseases		Pontocerebellar hypoplasia
GWAS		Deep white matter hyperintensities ( 32517579) FEV1 ( 30804560) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Lung function in never smokers (high FEV1 vs average FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Platelet count ( 32888494) Plateletcrit ( 32888494) Sight-threatening diabetic retinopathy in type 2 diabetes ( 26188370)	Early cardiac repolarization ( 31600170) Telomere length ( 21460395)
Interacting Genes		21 interacting genes: BRCA1 CCDC57 CLP1 CSNK2B GOLGA6L9 IRF4 KPNA5 KRT31 LHX3 LHX4 LMO2 MCPH1 MRPL38 NAA10 NCKIPSD NFKBID RINT1 TRIM23 TRIML2 TSEN2 ZMYND12	28 interacting genes: ANP32A ANP32B ARNT BRMS1 CDKN1B DCPS EPAS1 FAM214B FBXO7 HIF1A HNRNPC IL32 KAT5 LMNB1 MLH1 NMNAT1 NRF1 NUP50 POLR3C POU6F2 RAD52 RBBP4 SPOP SPOPL TSEN54 TWIST1 WT1 ZNF326
Entrez ID		283989	3841
HPRD ID		12291	05179
Ensembl ID		ENSG00000182173	ENSG00000196911
Uniprot IDs		Q7Z6J9	O15131
PDB IDs			4U2X
Enriched GO Terms of Interacting Partners?
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