BRICD5 and IFNGR2

Data Source:
BioGRID (two hybrid)

		BRICD5	IFNGR2
Description		BRICHOS domain containing 5	interferon gamma receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Integral Component Of Membrane	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane
	Molecular Function	Protein Binding	Cytokine Receptor Activity Interferon-gamma Receptor Activity Protein Binding
	Biological Process	Regulation Of Cell Population Proliferation	Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways			Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Potential therapeutics for SARS
Drugs			Interferon gamma-1b
Diseases			Tuberculosis IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
GWAS			Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 23128233) Diverticular disease ( 30177863) Educational attainment ( 25201988) Inflammatory bowel disease ( 28067908) Multiple sclerosis ( 31604244 24076602) Obesity-related traits ( 23251661) Psoriasis ( 25854761) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		41 interacting genes: AQP6 ARL13B BIK CD69 CD79A CLEC2D CLRN1 CREB3L1 FKBP7 HHLA2 HSD17B13 ICAM3 IFNGR2 IFNLR1 IL27RA KIR2DL3 KLRC1 LMNA LRRC25 LRRC4C MRM1 MTIF3 MUC1 NEMP1 PLEKHO1 PSCA PVR SCN3B SGCB SGPL1 SIGLEC9 SLAMF6 SLC18A1 SLC18A2 SORT1 SYNE4 TMEM234 TMEM248 TMEM79 TMPRSS2 TMX2	42 interacting genes: ADIPOQ ANXA5 BNIP3 BRICD5 BTNL8 CAMK2D CD302 CLDN19 CLEC7A CXCL9 DNAJA3 EMP3 ENTPD3 ERMP1 GIMAP5 IFNG IFNGR1 INSIG2 JAGN1 JAK2 NR3C1 PMP22 RPL37A RTP2 SEC22B SFT2D2 SFTPC SLC52A1 SMIM3 STRIT1 TMEM120B TMEM140 TMEM199 TMEM218 TMEM254 TMEM60 TMEM97 TRARG1 TREX1 TSPAN2 UNC50 ZDHHC24
Entrez ID		283870	3460
HPRD ID		14482	00956
Ensembl ID		ENSG00000182685	ENSG00000159128
Uniprot IDs		Q6PL45	A8K881 E7EUY1 P38484
PDB IDs			5EH1 6E3K 6E3L
Enriched GO Terms of Interacting Partners?
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