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GNB1 and AFP
Data Source:
BioGRID
(two hybrid)
GNB1
AFP
Description
G protein subunit beta 1
alpha fetoprotein
Image
GO Annotations
Cellular Component
Photoreceptor Inner Segment
Cytoplasm
Lysosomal Membrane
Cytosol
Heterotrimeric G-protein Complex
Plasma Membrane
Membrane
Dendrite
Photoreceptor Outer Segment Membrane
Cell Body
Synapse
Extracellular Exosome
Photoreceptor Disc Membrane
Extracellular Vesicle
Extracellular Space
Cytoplasm
Endoplasmic Reticulum Lumen
Molecular Function
GTPase Activity
Protein Binding
Spectrin Binding
G-protein Gamma-subunit Binding
Protein-containing Complex Binding
Alkylglycerophosphoethanolamine Phosphodiesterase Activity
GTPase Binding
Fatty Acid Binding
Protein Binding
Zinc Ion Binding
Biological Process
Protein Folding
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway
Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
G Protein-coupled Acetylcholine Receptor Signaling Pathway
Wnt Signaling Pathway, Calcium Modulating Pathway
Ras Protein Signal Transduction
Cell Population Proliferation
Cardiac Muscle Cell Apoptotic Process
Rhodopsin Mediated Signaling Pathway
Platelet Activation
Sensory Perception Of Taste
Retina Development In Camera-type Eye
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Hypoxia
Cellular Response To Catecholamine Stimulus
Transport
Post-translational Protein Modification
Cellular Protein Metabolic Process
Pathways
Activation of G protein gated Potassium channels
Glucagon signaling in metabolic regulation
G-protein activation
Activation of the phototransduction cascade
Activation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Olfactory Signaling Pathway
ADP signalling through P2Y purinoceptor 12
G beta:gamma signalling through PI3Kgamma
Prostacyclin signalling through prostacyclin receptor
Prostacyclin signalling through prostacyclin receptor
Adrenaline,noradrenaline inhibits insulin secretion
Adrenaline,noradrenaline inhibits insulin secretion
Ca2+ pathway
Ca2+ pathway
G alpha (q) signalling events
G alpha (12/13) signalling events
G beta:gamma signalling through PLC beta
G alpha (s) signalling events
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 1
G alpha (i) signalling events
G alpha (z) signalling events
Glucagon-type ligand receptors
Thromboxane signalling through TP receptor
Vasopressin regulates renal water homeostasis via Aquaporins
Thrombin signalling through proteinase activated receptors (PARs)
Thrombin signalling through proteinase activated receptors (PARs)
Presynaptic function of Kainate receptors
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
G beta:gamma signalling through BTK
G beta:gamma signalling through CDC42
Extra-nuclear estrogen signaling
ADORA2B mediated anti-inflammatory cytokines production
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation
Drugs
Diseases
GWAS
Body mass index (
26426971
25673413
)
Diastolic blood pressure (
27841878
)
Systolic blood pressure (
27841878
)
Blood protein levels (
30072576
)
Prostate cancer (
23535732
)
Tumor biomarkers (
23300138
)
Interacting Genes
43 interacting genes:
ADRA2A
ADRB2
AFP
ARHGEF18
ARRB1
ATXN10
AVPR2
CACNA1A
CACNA1B
CACNA1C
CDC42
CTNNA3
CYFIP1
DISC1
EPHA7
GNA12
GNAS
GNG10
GNG11
GNG12
GNG13
GNG2
GNG3
GNG4
GNG5
GNG7
GNG8
GNGT1
HDAC5
KCNJ3
MCF2
MRGPRX1
MTNR1A
MTNR1B
NOL11
NR3C1
PDCL
PTH1R
RACK1
RASD1
RASD2
TBXA2R
VAC14
14 interacting genes:
AP4S1
CASP3
CCR5
CREBBP
EHD4
GNB1
MED27
PHB2
PIDD1
PSMB7
PTEN
SGSM2
SIRT1
XIAP
Entrez ID
2782
174
HPRD ID
00766
00074
Ensembl ID
ENSG00000078369
ENSG00000081051
Uniprot IDs
A0A140VJJ8
B3KVK2
P62873
P02771
PDB IDs
4KFM
4PNK
5HE0
5HE1
5HE2
5HE3
5UKK
5UKL
5UKM
5UZ7
6B3J
6CRK
6D9H
6DDE
6DDF
6E3Y
6EG8
6G79
6GDG
6KPF
6KPG
6LFM
6LFO
6LI3
6LMK
6LML
6M1H
6M1I
6M8S
6N4B
6NI3
6NIY
6OIJ
6OIK
6OMM
6ORV
6OS9
6OSA
6OT0
6P9X
6P9Y
6PB0
6PB1
6PT0
6UUN
6UUS
6UVA
6VCB
6VMS
6VN7
6WHA
6WHC
6WI9
6WPW
6WZG
6X18
6X19
6X1A
6XBJ
6XBK
6XBL
6XBM
7C2E
7CFM
7CFN
7K7L
7K7Z
3MRK
Enriched GO Terms of Interacting Partners
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