MAT2B and RABEP1

Data Source:
BioGRID (two hybrid)

		MAT2B	RABEP1
Description		methionine adenosyltransferase 2B	rabaptin, RAB GTPase binding effector protein 1
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GO Annotations	Cellular Component	Nucleus Cytosol Methionine Adenosyltransferase Complex Extracellular Exosome	Endosome Early Endosome Endocytic Vesicle Early Endosome Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Recycling Endosome
	Molecular Function	Protein Binding Enzyme Binding Methionine Adenosyltransferase Regulator Activity	GTPase Activator Activity Protein Binding Growth Factor Activity Protein Domain Specific Binding Protein Homodimerization Activity
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Methylation Regulation Of Catalytic Activity	Golgi To Plasma Membrane Transport Endocytosis Apoptotic Process Signal Transduction Protein Transport Vesicle-mediated Transport Positive Regulation Of GTPase Activity Membrane Fusion Protein Localization To Ciliary Membrane
Pathways		Methylation Ub-specific processing proteases	TBC/RABGAPs
Drugs
Diseases
GWAS		Aging ( 22773346) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Broad depression or major depressive disorder (self-reported) ( 30626913) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) General risk tolerance (MTAG) ( 30643258) Methadone dose in opioid dependence ( 28115739) Neuritic plaque ( 31497858) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Smoking initiation ( 24665060) Uterine fibroid size (maximum dimension) ( 30196971) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)	Body mass index ( 28892062 25673413) Lymphocyte counts ( 32888494) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Red blood cell density in sickle cell anemia ( 28552477) White blood cell count ( 27863252)
Interacting Genes		10 interacting genes: APP FBXO25 HRH1 KPNA3 KPNA4 MAT2A PLA2G6 RABEP1 TEPSIN TRIM27	58 interacting genes: ABI2 AIMP2 AP1G1 AP1G2 ATXN7 BARD1 CASP3 CCDC120 CCND1 CDC73 CDK18 CDKL3 CEP57 CFAP53 ELOA ESCO2 FAM50B FAM90A1 GAP43 GGA1 GGA2 GGA3 HUNK ITSN1 LENG1 MAT2B MCRS1 ODAD3 PELI2 PKP2 PRPF3 RAB1A RAB33B RAB4A RAB4B RAB5A RABGEF1 RGS17 RNF39 SMURF1 SNAPIN SNW1 SRPK2 STAR TNS4 TRAPPC2L TRIM26 TSC2 TSHZ2 UBC UBTFL1 USP2 UTP14C WASHC3 YWHAG ZNF438 ZNF512B ZNF774
Entrez ID		27430	9135
HPRD ID		05701	04684
Ensembl ID		ENSG00000038274	ENSG00000029725
Uniprot IDs		A0A140VJP2 Q9NZL9	B4DMM4 Q15276
PDB IDs		2YDX 2YDY 4KTT 4KTV 4NDN	1P4U 1TU3 1X79 4N3Y 4N3Z 4Q9U
Enriched GO Terms of Interacting Partners?
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