MAT2B and TEPSIN

Data Source:
BioGRID (two hybrid)

		MAT2B	TEPSIN
Description		methionine adenosyltransferase 2B	TEPSIN adaptor related protein complex 4 accessory protein
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GO Annotations	Cellular Component	Nucleus Cytosol Methionine Adenosyltransferase Complex Extracellular Exosome	Cytoplasm Golgi Apparatus Cytosol Nuclear Speck AP-4 Adaptor Complex Coated Vesicle Membrane Extrinsic Component Of Organelle Membrane Nuclear Membrane Trans-Golgi Network Membrane
	Molecular Function	Protein Binding Enzyme Binding Methionine Adenosyltransferase Regulator Activity	Protein Binding
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Methylation Regulation Of Catalytic Activity
Pathways		Methylation Ub-specific processing proteases
Drugs
Diseases
GWAS		Aging ( 22773346) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Broad depression or major depressive disorder (self-reported) ( 30626913) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) General risk tolerance (MTAG) ( 30643258) Methadone dose in opioid dependence ( 28115739) Neuritic plaque ( 31497858) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Smoking initiation ( 24665060) Uterine fibroid size (maximum dimension) ( 30196971) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)	IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391)
Interacting Genes		10 interacting genes: APP FBXO25 HRH1 KPNA3 KPNA4 MAT2A PLA2G6 RABEP1 TEPSIN TRIM27	127 interacting genes: AATK ACBD7 AGRN AP1M1 AP4B1 APOL6 APP ASAP3 ASB3 BCL2L14 BCL2L15 BHLHB9 BIRC7 BPIFA1 BTBD3 C1orf109 C1QTNF4 CBX8 CCDC146 CCNC CDC23 CINP CLCNKA CLIC3 CNTF CPNE7 CSNK2A1 CTAG1A CTAG1B CYSRT1 DEF6 DUSP29 DUSP4 DZIP1L EIF1AD FAM214B FAM90A1 FARS2 FKBP6 FLACC1 FNDC3B GNG13 GOLGA2 GPANK1 GRB10 GRIPAP1 GUCD1 HAT1 HCK HPCA HSF2BP HSPB7 IL16 IQGAP1 KCTD6 KCTD9 KHNYN KLHL38 KRT31 KRT34 KRT35 KRTAP6-2 LENG1 LGALS14 LMO3 LSM3 LYG2 MAT2B MED18 MFAP1 MLX MORF4L1 MSGN1 MTUS2 NDOR1 NEK6 NGB NME7 NR2C2AP NTAQ1 NUDT14 NUDT21 OAZ3 OR6B1 PAX9 PCDHB3 PLEKHA2 PSMA6 RAB3IP RAD51D RANBP3 RNF135 SEC14L4 SLU7 SNRNP25 SORBS2 SORBS3 SZT2 TAPBPL TBC1D13 TBC1D22B TCEA2 TCL1A TFAP2D THRSP TRAPPC2 TRAPPC2B TRAPPC6A TRIM23 TRIM45 TRIM50 TRIM54 TRIM68 TSEN15 TSEN2 TSHZ3 TSSK3 UBASH3B UTP23 VPS26C WDR25 YPEL3 ZIC1 ZMYND12 ZNF343 ZNF629 ZRSR2
Entrez ID		27430	146705
HPRD ID		05701	08103
Ensembl ID		ENSG00000038274	ENSG00000167302
Uniprot IDs		A0A140VJP2 Q9NZL9	Q96N21
PDB IDs		2YDX 2YDY 4KTT 4KTV 4NDN	5WF9 5WFB
Enriched GO Terms of Interacting Partners?
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