MAT2B and FBXO25

Data Source:
BioGRID (enzymatic study)

		MAT2B	FBXO25
Description		methionine adenosyltransferase 2B	F-box protein 25
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Methionine Adenosyltransferase Complex Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Nucleolus SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Enzyme Binding Methionine Adenosyltransferase Regulator Activity	Actin Binding Ubiquitin-protein Transferase Activity
	Biological Process	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Methylation Regulation Of Catalytic Activity	Protein Ubiquitination
Pathways		Methylation Ub-specific processing proteases
Drugs
Diseases
GWAS		Aging ( 22773346) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Broad depression or major depressive disorder (self-reported) ( 30626913) Chronotype ( 30696823) Common carotid intima-media thickness ( 29206233) General risk tolerance (MTAG) ( 30643258) Methadone dose in opioid dependence ( 28115739) Neuritic plaque ( 31497858) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Possible neuropathic pain in post total joint replacement surgery for osteoarthritis ( 28051079) Smoking initiation ( 24665060) Uterine fibroid size (maximum dimension) ( 30196971) Very long-chain saturated fatty acid levels (fatty acid 22:0) ( 25378659) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		10 interacting genes: APP FBXO25 HRH1 KPNA3 KPNA4 MAT2A PLA2G6 RABEP1 TEPSIN TRIM27	82 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		27430	26260
HPRD ID		05701	16439
Ensembl ID		ENSG00000038274	ENSG00000147364
Uniprot IDs		A0A140VJP2 Q9NZL9	A0A024QZ88 Q8TCJ0
PDB IDs		2YDX 2YDY 4KTT 4KTV 4NDN
Enriched GO Terms of Interacting Partners?
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