KLHL20 and ECT2

Data Source:
HPRD (two hybrid)

		KLHL20	ECT2
Description		kelch like family member 20	epithelial cell transforming 2
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Cell-cell Junction Bicellular Tight Junction Cell Cortex Nuclear Body Midbody Cleavage Furrow Mitotic Spindle Centralspindlin Complex
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Interferon-gamma Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Protein K33-linked Ubiquitination	Mitotic Cytokinesis Cell Morphogenesis G Protein-coupled Receptor Signaling Pathway Nervous System Development Protein Transport Cell Differentiation Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Feeling miserable ( 29500382)	Obesity-related traits ( 23251661) Red cell distribution width ( 32888494)
Interacting Genes		41 interacting genes: ACTA1 ARHGEF12 ATG9A BCL6 BEX1 BEX2 C1orf216 C20orf85 C21orf58 CEP126 CIDEC CLCNKA COL8A1 CORO7 CRK CRMP1 DUSP21 ECT2 ENKD1 EPAS1 ERG28 GBP2 HR IVNS1ABP KLHL38 LRIF1 LUC7L2 MTNR1A NEDD9 NTAQ1 PIN1 PML PRMT6 RANBP3 RECK SLC13A5 STK16 SUV39H1 TFAP2D TNPO2 USP20	38 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 LAMTOR5 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB VDAC2
Entrez ID		27252	1894
HPRD ID		13918	11860
Ensembl ID		ENSG00000076321	ENSG00000114346
Uniprot IDs		Q9Y2M5	Q9H8V3
PDB IDs		5YQ4 6GY5	3L46 4N40 6L30
Enriched GO Terms of Interacting Partners?
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