DAPP1 and PLAGL2

Data Source:
BioGRID (two hybrid)

		DAPP1	PLAGL2
Description		dual adaptor of phosphotyrosine and 3-phosphoinositides 1	PLAG1 like zinc finger 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Nucleus
	Molecular Function	Protein Binding Phospholipid Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Protein Dephosphorylation Signal Transduction	Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Post-embryonic Development Chylomicron Assembly Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS		Red cell distribution width ( 32888494)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908)
Interacting Genes		23 interacting genes: BTK CNDP2 ERBB3 FAIM FCHSD2 FXN GSTCD HSD3B7 HSPA1A LCK LYN MAP4K1 MGARP MYLIP PLAGL2 PLCG1 PLCG2 RBP7 RPL23 SRC TM4SF19 TNFAIP1 ZNHIT1	44 interacting genes: ANKRD11 ARID5A BCAS2 CATSPER1 CCDC120 CTNNA3 DAPP1 DHX57 DVL3 FAM161B FAM83A FAM90A1 GEM GLYCTK GPATCH2L GYS1 INO80B IRX2 KANK2 MAD2L2 MAPK1 MORN4 NOS1AP OIP5 OLIG3 PAX9 PHC2 PIN1 PLAC8 PRR35 RCHY1 RHOBTB3 RIPPLY1 SAMD11 SEPHS1 SMARCD1 TEKT3 TEKT4 TRAF4 TRIM41 VEZF1 YPEL5 ZNF564 ZNF581
Entrez ID		27071	5326
HPRD ID		05773	05333
Ensembl ID		ENSG00000070190	ENSG00000126003
Uniprot IDs		J3KNB3 Q9UN19	Q9UPG8
PDB IDs		1FAO 1FB8
Enriched GO Terms of Interacting Partners?
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