DAPP1 and MAP4K1

Data Source:
HPRD (in vitro, in vivo)

		DAPP1	MAP4K1
Description		dual adaptor of phosphotyrosine and 3-phosphoinositides 1	mitogen-activated protein kinase kinase kinase kinase 1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane	Membrane
	Molecular Function	Protein Binding Phospholipid Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Dephosphorylation Signal Transduction	Activation Of MAPKKK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Cell Population Proliferation Peptidyl-serine Phosphorylation Protein Autophosphorylation Cellular Response To Phorbol 13-acetate 12-myristate
Pathways		Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs		Inositol 1,3,4,5-Tetrakisphosphate	Fostamatinib
Diseases
GWAS		Red cell distribution width ( 32888494)	Diisocyanate-induced asthma ( 25918132)
Interacting Genes		23 interacting genes: BTK CNDP2 ERBB3 FAIM FCHSD2 FXN GSTCD HSD3B7 HSPA1A LCK LYN MAP4K1 MGARP MYLIP PLAGL2 PLCG1 PLCG2 RBP7 RPL23 SRC TM4SF19 TNFAIP1 ZNHIT1	22 interacting genes: ABL1 BLNK CARD11 CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 H2AC4 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 SHC1 SYK TMEM101
Entrez ID		27071	11184
HPRD ID		05773	03583
Ensembl ID		ENSG00000070190	ENSG00000104814
Uniprot IDs		J3KNB3 Q9UN19	Q92918
PDB IDs		1FAO 1FB8	6CQD 6CQE 6CQF 6NFY 6NFZ 6NG0
Enriched GO Terms of Interacting Partners?
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