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LDLRAP1 and MAPK8IP3
Data Source:
BioGRID
(two hybrid, two hybrid)
LDLRAP1
MAPK8IP3
Description
low density lipoprotein receptor adaptor protein 1
mitogen-activated protein kinase 8 interacting protein 3
Image
GO Annotations
Cellular Component
Early Endosome
Cytosol
Neurofilament
Plasma Membrane
Cytoplasmic Side Of Plasma Membrane
Basal Plasma Membrane
Axon
Clathrin-coated Vesicle Membrane
Recycling Endosome
Golgi Membrane
Cytoplasm
Axon
Dendrite
Growth Cone
Cytoplasmic Vesicle
Cell Body
Perinuclear Region Of Cytoplasm
Axon Cytoplasm
Molecular Function
Amyloid-beta Binding
Phosphotyrosine Residue Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Signaling Receptor Complex Adaptor Activity
Clathrin Binding
Signaling Adaptor Activity
AP-2 Adaptor Complex Binding
Clathrin Adaptor Activity
AP-1 Adaptor Complex Binding
Low-density Lipoprotein Particle Receptor Binding
MAP-kinase Scaffold Activity
Protein Binding
JUN Kinase Binding
Kinesin Binding
Signaling Receptor Complex Adaptor Activity
Biological Process
Receptor-mediated Endocytosis
Cholesterol Metabolic Process
Cholesterol Transport
Receptor Internalization
Low-density Lipoprotein Particle Clearance
Cholesterol Homeostasis
Amyloid Precursor Protein Metabolic Process
Regulation Of Protein Binding
Positive Regulation Of Receptor-mediated Endocytosis
Membrane Organization
Cellular Response To Cytokine Stimulus
Receptor-mediated Endocytosis Involved In Cholesterol Transport
Positive Regulation Of Cholesterol Metabolic Process
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Positive Regulation Of Low-density Lipoprotein Particle Clearance
Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Activation Of JUN Kinase Activity
Vesicle-mediated Transport
Axon Regeneration
Regulation Of JNK Cascade
Axon Development
Anterograde Axonal Protein Transport
Pathways
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Chylomicron clearance
LDL clearance
Drugs
Diseases
GWAS
Cholesterol, total (
24097068
25961943
20686565
)
LDL cholesterol (
24097068
25961943
20686565
)
LDL cholesterol levels (
28334899
)
Mean platelet volume (
32888494
27863252
)
Platelet count (
32888494
27863252
)
Platelet distribution width (
32888494
)
Total cholesterol levels (
28334899
)
Intraocular pressure (
29617998
)
Interacting Genes
18 interacting genes:
AP1B1
AP2B1
APP
C6orf58
CLTC
ESPNL
FHL2
HOXC8
HOXD8
LDLR
LRP2
MAGEA4
MAPK8IP3
NOTO
PAX5
PSD4
STN1
TFAP2A
26 interacting genes:
ARL4D
CASP3
KLC1
KLC2
LDLRAP1
MAP2K1
MAP2K4
MAP2K7
MAP3K11
MAP3K5
MAPK10
MAPK8
MAPK8IP1
MAPK8IP2
MAPK9
PTK2
RAD51
RAD51D
RAF1
RIC8A
SRC
SULT4A1
TLR2
TLR4
TLR9
ZNF575
Entrez ID
26119
23162
HPRD ID
05765
12014
Ensembl ID
ENSG00000157978
ENSG00000138834
Uniprot IDs
B3KR97
Q5SW96
A0A087WYG2
B7ZMF3
E9PFH7
Q9UPT6
PDB IDs
2G30
4PXJ
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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