LDLRAP1 and PAX5

Data Source:
BioGRID (two hybrid)

		LDLRAP1	PAX5
Description		low density lipoprotein receptor adaptor protein 1	paired box 5
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GO Annotations	Cellular Component	Early Endosome Cytosol Neurofilament Plasma Membrane Cytoplasmic Side Of Plasma Membrane Basal Plasma Membrane Axon Clathrin-coated Vesicle Membrane Recycling Endosome	Chromatin Fibrillar Center Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Amyloid-beta Binding Phosphotyrosine Residue Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Signaling Receptor Complex Adaptor Activity Clathrin Binding Signaling Adaptor Activity AP-2 Adaptor Complex Binding Clathrin Adaptor Activity AP-1 Adaptor Complex Binding Low-density Lipoprotein Particle Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Receptor-mediated Endocytosis Cholesterol Metabolic Process Cholesterol Transport Receptor Internalization Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Receptor-mediated Endocytosis Membrane Organization Cellular Response To Cytokine Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Humoral Immune Response Multicellular Organism Development Spermatogenesis Aging Animal Organ Morphogenesis Lateral Ventricle Development Cerebral Cortex Development Adult Behavior Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Cranial Skeleton Morphogenesis Anatomical Structure Development Regulation Of B Cell Receptor Signaling Pathway Negative Regulation Of Histone H3-K9 Methylation
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance LDL clearance	RUNX1 regulates transcription of genes involved in BCR signaling
Drugs
Diseases			Lymphoplasmacytic lymphoma
GWAS		Cholesterol, total ( 24097068 25961943 20686565) LDL cholesterol ( 24097068 25961943 20686565) LDL cholesterol levels ( 28334899) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Total cholesterol levels ( 28334899)	Adult body size ( 32376654) Alzheimer's disease ( 30636644) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Coronary artery disease in type 1 diabetes ( 29695241) HIV-1 susceptibility ( 25786224) Intelligence ( 22449649) Major depressive disorder ( 27479909) Moderate to vigorous physical activity levels ( 29899525) Morning person ( 30696823) Obesity-related traits ( 22013104)
Interacting Genes		18 interacting genes: AP1B1 AP2B1 APP C6orf58 CLTC ESPNL FHL2 HOXC8 HOXD8 LDLR LRP2 MAGEA4 MAPK8IP3 NOTO PAX5 PSD4 STN1 TFAP2A	55 interacting genes: ACOT12 BCAS2 C1orf109 CCNC CDK3 CIB3 CKS1B CREBBP CSNK2A1 CXorf38 DAXX DTX2 EBF1 EP300 ETS1 FBLN1 GNG13 GRHL2 HGS HMBOX1 HMGB3 HOXC8 ID2 ID3 KLHL38 KPNA1 KPNA2 KRTAP10-8 KRTAP9-3 LARP4 LDLRAP1 LONRF1 MAPK1 MAPK9 MYB NEIL2 NFYC NGLY1 OSGIN1 PNMA5 RAD52 RB1 RNF144B RUNX1 SAE1 SEC14L4 STAC TBP TLE4 TLK2 UBE2I UBE3A UBXN2B UBXN7 ZMYM5
Entrez ID		26119	5079
HPRD ID		05765	01334
Ensembl ID		ENSG00000157978	ENSG00000196092
Uniprot IDs		B3KR97 Q5SW96	C0KTE5 C0KTF5 E7EQT0 E7ERK2 E7ERW5 E7ES87 Q02548
PDB IDs		2G30	1K78 1MDM
Enriched GO Terms of Interacting Partners?
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