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SIN3A and SMARCE1
Data Source:
BioGRID
(pull down)
SIN3A
SMARCE1
Description
SIN3 transcription regulator family member A
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Kinetochore
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Sin3 Complex
Transcription Repressor Complex
Nuclear Chromosome
Chromatin
Nucleus
Nucleoplasm
SWI/SNF Complex
Protein-containing Complex
NpBAF Complex
NBAF Complex
Molecular Function
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Protein Binding
Protein-containing Complex Binding
Transcription Regulator Inhibitor Activity
Chromatin Binding
Transcription Coactivator Activity
RNA Binding
Protein Binding
N-acetyltransferase Activity
Nuclear Receptor Binding
Nucleosomal DNA Binding
Protein N-terminus Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Hematopoietic Progenitor Cell Differentiation
DNA Replication
Protein Deacetylation
Aging
Regulation Of Hormone Levels
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Histone Deacetylation
Regulation Of Lipid Metabolic Process
Cerebral Cortex Neuron Differentiation
Regulation Of Axon Extension
Positive Regulation Of Chromatin Silencing
Cellular Protein Localization
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Response To Methylglyoxal
Cellular Response To Glucose Stimulus
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of Histone H3-K27 Acetylation
Cellular Response To Dopamine
Negative Regulation Of Transcription Regulatory Region DNA Binding
Nucleosome Disassembly
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Neurogenesis
ATP-dependent Chromatin Remodeling
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Pathways
SUMOylation of transcription cofactors
Regulation of lipid metabolism by PPARalpha
NoRC negatively regulates rRNA expression
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Loss of MECP2 binding ability to 5mC-DNA
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Factors involved in megakaryocyte development and platelet production
RMTs methylate histone arginines
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Drugs
Phenethyl Isothiocyanate
Diseases
GWAS
Estimated glomerular filtration rate (
31152163
)
Height (
20189936
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
)
Sudden cardiac arrest (
21658281
)
Type 2 diabetes (
32499647
)
Allergic disease (asthma, hay fever and/or eczema) (age of onset) (
32603359
)
Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) (
32603359
)
Allergic disease (asthma, hay fever or eczema) (
29083406
29785011
)
Allergic rhinitis (
31361310
)
Asthma (
31959851
30929738
31619474
)
Asthma (childhood onset) (
30929738
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Eczema (
31361310
)
Interacting Genes
98 interacting genes:
ARID4A
ARID4B
BCL11A
BCL6
BCL6B
BHLHE40
BNIP2
BRMS1
BRMS1L
CBFA2T2
CIAO2A
COPS2
CTBP1
CTCF
CUL4B
CYTOR
DACH1
DDB1
DDX20
DHX30
ETV6
FOXK2
H3-4
HBP1
HCFC1
HDAC1
HDAC2
HDAC7
HDAC9
HEY2
HTT
IKZF1
IKZF4
ING1
IRF5
KLF10
KLF11
KLF13
KLF16
KLF9
LRCH4
MAD1L1
MBD2
MBD4
MECP2
MEN1
MNT
MORF4L2
MXD1
MXD4
MXI1
MYB
NCOR2
NDRG4
NFKB1
NFKB2
NR2E3
OGT
PA2G4
PBX3
PHB
PHF12
PML
PRMT5
PTEN
PTMA
RBBP4
RBBP7
RBP1
RBPJ
REL
RELA
RELB
RLIM
RUNX1T1
SAP18
SAP30
SETDB1
SFPQ
SH3GLB1
SKI
SMAD3
SMARCA4
SMARCC1
SMARCE1
SNW1
SPI1
STAT3
SUMO2
SYT1
TAL1
TFCP2
TGIF1
THAP11
TOPORS
TP53
TRIM28
ZBTB16
89 interacting genes:
AMOTL2
AR
ARID2
BAZ1B
BRAP
BRMS1
CCDC136
CCDC172
CCDC183
CCHCR1
CDR2
CEP170P1
CEP63
CEP70
CYSRT1
DISC1
EPS8
ESR1
ESR2
EXOC4
EXOC7
FAM217B
FSD2
GATA1
GOLGA2
GOLGA6L9
GRIPAP1
IFT74
IFT88
ING5
ITCH
JAKMIP2
KIFC3
KLF1
KRT14
KRT15
KRT16
KRT19
KRT27
KRT31
KRT34
KRT35
KRT37
KRT39
KRT40
KRTAP1-1
KRTAP10-8
KRTAP10-9
KRTAP6-3
MDM2
MED4
MEOX2
MIPOL1
MRFAP1L1
MTUS2
NBPF22P
NCOA1
NCOA2
NCOA3
NOTCH2NLA
NR0B2
NR3C1
NUP62
OIP5
PGR
PRMT5
PSMC6
RALBP1
RARB
RCOR1
RELB
RINT1
SIN3A
SIN3B
SMAD1
SMARCA4
SPAG5
SRC
STX11
SYCE1
TEX12
TFE3
TFIP11
TNIK
TRIM54
TRIP10
TXLNA
USHBP1
VPS52
Entrez ID
25942
6605
HPRD ID
09690
04382
Ensembl ID
ENSG00000169375
ENSG00000073584
Uniprot IDs
Q96ST3
A0A024R1S7
Q969G3
PDB IDs
1PO4
6LTH
6LTJ
7CYU
Enriched GO Terms of Interacting Partners
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