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SIN3A and SNW1
Data Source:
BioGRID
(pull down)
SIN3A
SNW1
Description
SIN3 transcription regulator family member A
SNW domain containing 1
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Kinetochore
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Sin3 Complex
Transcription Repressor Complex
Nucleus
Nucleoplasm
Spliceosomal Complex
Cyclin/CDK Positive Transcription Elongation Factor Complex
Nuclear Matrix
Nuclear Body
Nuclear Speck
U2-type Catalytic Step 2 Spliceosome
Catalytic Step 2 Spliceosome
Molecular Function
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Protein Binding
Protein-containing Complex Binding
Transcription Regulator Inhibitor Activity
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Notch Binding
Protein Binding
Enzyme Binding
Nuclear Hormone Receptor Binding
Vitamin D Receptor Binding
Retinoic Acid Receptor Binding
SMAD Binding
Androgen Receptor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Hematopoietic Progenitor Cell Differentiation
DNA Replication
Protein Deacetylation
Aging
Regulation Of Hormone Levels
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Histone Deacetylation
Regulation Of Lipid Metabolic Process
Cerebral Cortex Neuron Differentiation
Regulation Of Axon Extension
Positive Regulation Of Chromatin Silencing
Cellular Protein Localization
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Response To Methylglyoxal
Cellular Response To Glucose Stimulus
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of Histone H3-K27 Acetylation
Cellular Response To Dopamine
Negative Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Transcription By RNA Polymerase II
MRNA Splicing, Via Spliceosome
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Notch Signaling Pathway
Positive Regulation Of Transcription Of Notch Receptor Target
Viral Process
Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation By Host Of Viral Transcription
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of MRNA Splicing, Via Spliceosome
Retinoic Acid Receptor Signaling Pathway
Regulation Of Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Neurogenesis
Positive Regulation Of Histone H3-K4 Methylation
Regulation Of Vitamin D Receptor Signaling Pathway
Positive Regulation Of Vitamin D Receptor Signaling Pathway
Cellular Response To Retinoic Acid
Pathways
SUMOylation of transcription cofactors
Regulation of lipid metabolism by PPARalpha
NoRC negatively regulates rRNA expression
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Loss of MECP2 binding ability to 5mC-DNA
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Factors involved in megakaryocyte development and platelet production
Pre-NOTCH Transcription and Translation
Pre-NOTCH Transcription and Translation
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
NOTCH1 Intracellular Domain Regulates Transcription
NOTCH1 Intracellular Domain Regulates Transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Notch-HLH transcription pathway
mRNA Splicing - Major Pathway
RUNX3 regulates NOTCH signaling
RUNX3 regulates NOTCH signaling
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH3 Intracellular Domain Regulates Transcription
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
GWAS
Estimated glomerular filtration rate (
31152163
)
Height (
20189936
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
)
Sudden cardiac arrest (
21658281
)
Type 2 diabetes (
32499647
)
Response to platinum-based chemotherapy in non-small-cell lung cancer (
22872573
)
Interacting Genes
98 interacting genes:
ARID4A
ARID4B
BCL11A
BCL6
BCL6B
BHLHE40
BNIP2
BRMS1
BRMS1L
CBFA2T2
CIAO2A
COPS2
CTBP1
CTCF
CUL4B
CYTOR
DACH1
DDB1
DDX20
DHX30
ETV6
FOXK2
H3-4
HBP1
HCFC1
HDAC1
HDAC2
HDAC7
HDAC9
HEY2
HTT
IKZF1
IKZF4
ING1
IRF5
KLF10
KLF11
KLF13
KLF16
KLF9
LRCH4
MAD1L1
MBD2
MBD4
MECP2
MEN1
MNT
MORF4L2
MXD1
MXD4
MXI1
MYB
NCOR2
NDRG4
NFKB1
NFKB2
NR2E3
OGT
PA2G4
PBX3
PHB
PHF12
PML
PRMT5
PTEN
PTMA
RBBP4
RBBP7
RBP1
RBPJ
REL
RELA
RELB
RLIM
RUNX1T1
SAP18
SAP30
SETDB1
SFPQ
SH3GLB1
SKI
SMAD3
SMARCA4
SMARCC1
SMARCE1
SNW1
SPI1
STAT3
SUMO2
SYT1
TAL1
TFCP2
TGIF1
THAP11
TOPORS
TP53
TRIM28
ZBTB16
97 interacting genes:
ABLIM3
ACTN2
ASCC2
BICD2
BYSL
C1orf216
CCDC125
CEP55
CEP70
CIR1
CWF19L2
DAXX
EP300
ERCC3
EXOSC5
FAM90A1
GABPB1
GAS2L2
GOLGA2
GRIPAP1
HDAC2
HMBOX1
HOOK2
HSF2BP
IKBKG
IKZF1
JDP2
KANK2
KRT40
LRP2BP
LZTS2
MAGEA1
MAGOHB
MAPK6
MCMBP
MEN1
MFAP1
MISP
MSL1
MTUS2
NCK2
NCOA1
NCOR1
NCOR2
NOTCH1
NOTCH3
NR0B1
NR0B2
NXF1
OCLN
ODF2
OSTF1
PABPN1
PCBD2
PGR
PICK1
PPIL1
PRKAA2
PRKAR1B
RABEP1
RARA
RB1
RBL1
RBL2
RBPJ
RINT1
RXRA
SAAL1
SART1
SIN3A
SIRT1
SKI
SMAD2
SMAD3
SMAD4
SNRNP200
SNU13
SPECC1L
STEEP1
SUMO2
TCP11L1
TEX11
TFIP11
TNNT1
TOP1
TRAF1
TRIM15
TRIM23
TRIM55
TRIM63
TTC14
USF1
VAV2
VDR
VPS39
WBP4
ZSCAN1
Entrez ID
25942
22938
HPRD ID
09690
04340
Ensembl ID
ENSG00000169375
ENSG00000100603
Uniprot IDs
Q96ST3
G3V3A4
Q13573
PDB IDs
1PO4
5MQF
5XJC
5YZG
5Z58
6FF4
6FF7
6ICZ
6ID0
6ID1
6QDV
6ZYM
7A5P
Enriched GO Terms of Interacting Partners
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