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SIN3A and BCL6
Data Source:
HPRD
(in vivo, in vitro)
SIN3A
BCL6
Description
SIN3 transcription regulator family member A
BCL6 transcription repressor
Image
GO Annotations
Cellular Component
Histone Deacetylase Complex
Kinetochore
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Sin3 Complex
Transcription Repressor Complex
Nucleus
Nucleoplasm
Replication Fork
Nucleolus
Golgi Apparatus
Molecular Function
RNA Polymerase II Activating Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Protein Binding
Protein-containing Complex Binding
Transcription Regulator Inhibitor Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Intronic Transcription Regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Chromatin DNA Binding
Identical Protein Binding
Sequence-specific DNA Binding
Metal Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Hematopoietic Progenitor Cell Differentiation
DNA Replication
Protein Deacetylation
Aging
Regulation Of Hormone Levels
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Histone Deacetylation
Regulation Of Lipid Metabolic Process
Cerebral Cortex Neuron Differentiation
Regulation Of Axon Extension
Positive Regulation Of Chromatin Silencing
Cellular Protein Localization
Negative Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Regulation Of Megakaryocyte Differentiation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Response To Methylglyoxal
Cellular Response To Glucose Stimulus
Negative Regulation Of Protein Localization To Nucleus
Negative Regulation Of Histone H3-K27 Acetylation
Cellular Response To Dopamine
Negative Regulation Of Transcription Regulatory Region DNA Binding
Negative Regulation Of Transcription By RNA Polymerase II
Cell Morphogenesis
Regulation Of Cytokine Production
Negative Regulation Of Cell-matrix Adhesion
Germinal Center Formation
Regulation Of Germinal Center Formation
Regulation Of Immune System Process
Negative Regulation Of B Cell Apoptotic Process
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Cellular Response To DNA Damage Stimulus
Rho Protein Signal Transduction
Spermatogenesis
Protein Localization
Negative Regulation Of Cell Population Proliferation
Cytokine-mediated Signaling Pathway
Actin Cytoskeleton Organization
B Cell Differentiation
Negative Regulation Of Cell Growth
Positive Regulation Of B Cell Proliferation
Positive Regulation Of Histone Deacetylation
Negative Regulation Of Mast Cell Cytokine Production
Negative Regulation Of Rho Protein Signal Transduction
Type 2 Immune Response
Regulation Of Cell Population Proliferation
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Regulation Of GTPase Activity
Regulation Of Memory T Cell Differentiation
Positive Regulation Of Regulatory T Cell Differentiation
Regulation Of Cell Differentiation
Negative Regulation Of T-helper 2 Cell Differentiation
Positive Regulation Of Neuron Differentiation
Negative Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Isotype Switching To IgE Isotypes
Erythrocyte Development
Regulation Of Inflammatory Response
Regulation Of Immune Response
Positive Regulation Of Cellular Component Movement
Negative Regulation Of Mitotic Cell Cycle DNA Replication
Negative Regulation Of Cellular Senescence
Pathways
SUMOylation of transcription cofactors
Regulation of lipid metabolism by PPARalpha
NoRC negatively regulates rRNA expression
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Loss of MECP2 binding ability to 5mC-DNA
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
MECP2 regulates transcription of neuronal ligands
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Factors involved in megakaryocyte development and platelet production
Interleukin-4 and Interleukin-13 signaling
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
FOXO-mediated transcription of cell death genes
Drugs
Diseases
Hairy-cell leukemia
GWAS
Estimated glomerular filtration rate (
31152163
)
Height (
20189936
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
)
Sudden cardiac arrest (
21658281
)
Type 2 diabetes (
32499647
)
Adverse response to drug (
30420678
)
Allergic disease (asthma, hay fever or eczema) (
29083406
)
Allergic rhinitis (
31361310
)
Allergic sensitization (
23817571
)
Asthma (
31959851
)
B cell non-Hodgkin lymphoma (
23749188
)
Basophil percentage of granulocytes (
27863252
)
Basophil percentage of white cells (
32888494
27863252
)
Blood urea nitrogen levels (
29403010
)
Glucose homeostasis traits (
25524916
)
Granulocyte percentage of myeloid white cells (
27863252
)
Height (
31562340
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of white cells (
32888494
)
PR interval (
23534349
)
Pulmonary function (smoking interaction) (
23284291
)
Renal function-related traits (BUN) (
22797727
)
Selective IgA deficiency (
27723758
)
Self-reported allergy (
23817569
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
25760438
)
Interacting Genes
98 interacting genes:
ARID4A
ARID4B
BCL11A
BCL6
BCL6B
BHLHE40
BNIP2
BRMS1
BRMS1L
CBFA2T2
CIAO2A
COPS2
CTBP1
CTCF
CUL4B
CYTOR
DACH1
DDB1
DDX20
DHX30
ETV6
FOXK2
H3-4
HBP1
HCFC1
HDAC1
HDAC2
HDAC7
HDAC9
HEY2
HTT
IKZF1
IKZF4
ING1
IRF5
KLF10
KLF11
KLF13
KLF16
KLF9
LRCH4
MAD1L1
MBD2
MBD4
MECP2
MEN1
MNT
MORF4L2
MXD1
MXD4
MXI1
MYB
NCOR2
NDRG4
NFKB1
NFKB2
NR2E3
OGT
PA2G4
PBX3
PHB
PHF12
PML
PRMT5
PTEN
PTMA
RBBP4
RBBP7
RBP1
RBPJ
REL
RELA
RELB
RLIM
RUNX1T1
SAP18
SAP30
SETDB1
SFPQ
SH3GLB1
SKI
SMAD3
SMARCA4
SMARCC1
SMARCE1
SNW1
SPI1
STAT3
SUMO2
SYT1
TAL1
TFCP2
TGIF1
THAP11
TOPORS
TP53
TRIM28
ZBTB16
89 interacting genes:
ANKRD53
ARHGEF9
ARRDC3
ATP23
BCL11A
BCL6B
BCOR
BLZF1
C4orf45
C7orf31
C9orf24
CABP4
CDK19
CDK8
CFAP161
CFAP97D1
CHD3
CNOT2
CRBN
CREBBP
CTNNB1
CUTC
DVL2
ENO1
EP300
FBXO11
GATA1
GLRX3
GOLGA2
HDAC1
HDAC4
HDAC5
HDAC7
HDAC9
IHO1
IRF4
JUN
JUNB
JUND
KIFC3
KLHL12
KLHL20
KRTAP13-1
KRTAP13-2
KRTAP19-1
LIMS3
LIMS4
MAPK1
MDFI
MED17
MED6
MTA3
MTUS2
NCOR1
NCOR2
PBX4
PELI1
PFDN5
PIN1
PML
POF1B
PPARD
PPTC7
PRKD3
PSMB4
RAF1
REL
RUNX1T1
SIAH1
SIN3A
SP1
SPI1
SSX2IP
TEKT4
TFIP11
TLE5
TP53
TP53BP1
TRAF1
TRAF2
TRIB3
TWIST1
WDR83
WNK4
ZBTB16
ZBTB17
ZBTB7A
ZBTB7B
ZNHIT1
Entrez ID
25942
604
HPRD ID
09690
00180
Ensembl ID
ENSG00000169375
ENSG00000113916
Uniprot IDs
Q96ST3
B5B0A5
P41182
PDB IDs
1PO4
1R28
1R29
1R2B
2EN2
2EOS
2LCE
2YRM
3BIM
3E4U
3LBZ
4CP3
4U2M
5H7G
5H7H
5MW2
5MW6
5MWD
5N1X
5N1Z
5N20
5N21
5X4M
5X4N
5X4O
5X4P
5X4Q
5X9O
5X9P
6C3L
6C3N
6CQ1
6EW6
6EW7
6EW8
6TOF
6TOG
6TOH
6TOI
6TOJ
6TOK
6TOL
6TOM
6TON
6TOO
Enriched GO Terms of Interacting Partners
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