ALS2CL and RAB5C

Data Source:
BioGRID (two hybrid)

		ALS2CL	RAB5C
Description		ALS2 C-terminal like	RAB5C, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Lysosomal Membrane Endosome Early Endosome Lipid Droplet Plasma Membrane Endomembrane System Endocytic Vesicle Early Endosome Membrane Azurophil Granule Membrane Melanosome Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Identical Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Endosome Organization Positive Regulation Of GTPase Activity	Intracellular Protein Transport Endocytosis Regulation Of Endocytosis Neutrophil Degranulation Plasma Membrane To Endosome Transport
Pathways		RAB GEFs exchange GTP for GDP on RABs	Golgi Associated Vesicle Biogenesis Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS			Coronary artery disease ( 29212778) Fibrinogen levels ( 28107422 26561523) Mean corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Vitiligo ( 27723757) vWF and FVIII levels ( 30586737) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: EEF1AKMT3 PPP1R32 RAB22A RAB31 RAB5A RAB5C RSPH14	15 interacting genes: ALS2CL APP APPL2 EEA1 ERBB2 GLP1R HRAS INCA1 RABAC1 RBSN RIN2 RIN3 SGSM3 TBC1D15 TBC1D17
Entrez ID		259173	5878
HPRD ID		10643	04947
Ensembl ID		ENSG00000178038	ENSG00000108774
Uniprot IDs		A0A024R2U1 Q60I27	A0A024R1U4 P51148
PDB IDs			4KYI
Enriched GO Terms of Interacting Partners?
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