PSD4 and LDLRAP1

Data Source:
BioGRID (two hybrid, two hybrid)

		PSD4	LDLRAP1
Description		pleckstrin and Sec7 domain containing 4	low density lipoprotein receptor adaptor protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Cleavage Furrow Ruffle Membrane	Early Endosome Cytosol Neurofilament Plasma Membrane Cytoplasmic Side Of Plasma Membrane Basal Plasma Membrane Axon Clathrin-coated Vesicle Membrane Recycling Endosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Phospholipid Binding	Amyloid-beta Binding Phosphotyrosine Residue Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Signaling Receptor Complex Adaptor Activity Clathrin Binding Signaling Adaptor Activity AP-2 Adaptor Complex Binding Clathrin Adaptor Activity AP-1 Adaptor Complex Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity	Receptor-mediated Endocytosis Cholesterol Metabolic Process Cholesterol Transport Receptor Internalization Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Receptor-mediated Endocytosis Membrane Organization Cellular Response To Cytokine Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Pathways			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance LDL clearance
Drugs
Diseases
GWAS		Chronic kidney disease ( 31152163) Creatinine levels ( 29403010) Diastolic blood pressure ( 28548082) Estimated glomerular filtration rate ( 31152163 30604766) Glomerular filtration rate ( 29403010) Hematocrit ( 32888494 27863252) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Red blood cell count ( 32888494 27863252) White blood cell count ( 32888494)	Cholesterol, total ( 24097068 25961943 20686565) LDL cholesterol ( 24097068 25961943 20686565) LDL cholesterol levels ( 28334899) Mean platelet volume ( 32888494 27863252) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Total cholesterol levels ( 28334899)
Interacting Genes		2 interacting genes: LDLRAP1 USP9X	18 interacting genes: AP1B1 AP2B1 APP C6orf58 CLTC ESPNL FHL2 HOXC8 HOXD8 LDLR LRP2 MAGEA4 MAPK8IP3 NOTO PAX5 PSD4 STN1 TFAP2A
Entrez ID		23550	26119
HPRD ID		15191	05765
Ensembl ID		ENSG00000125637	ENSG00000157978
Uniprot IDs		Q8NDX1	B3KR97 Q5SW96
PDB IDs			2G30
Enriched GO Terms of Interacting Partners?
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