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TBC1D1 and CALM2
Data Source:
BioGRID
(two hybrid)
TBC1D1
CALM2
Description
TBC1 domain family member 1
calmodulin 2
Image
GO Annotations
Cellular Component
Nucleus
Cytosol
Spindle Pole
Nucleus
Cytoplasm
Centrosome
Spindle Microtubule
Plasma Membrane
Sarcomere
Vesicle
Protein-containing Complex
Calcium Channel Complex
Catalytic Complex
Molecular Function
GTPase Activator Activity
Protein Binding
Calcium Ion Binding
Protein Binding
Adenylate Cyclase Binding
Adenylate Cyclase Activator Activity
Calcium Channel Inhibitor Activity
Protein Kinase Binding
Protein Domain Specific Binding
Enzyme Regulator Activity
Titin Binding
N-terminal Myristoylation Domain Binding
Protein Serine/threonine Kinase Activator Activity
Ion Channel Binding
Protein Phosphatase Activator Activity
Disordered Domain Specific Binding
Biological Process
Intracellular Protein Transport
Regulation Of Protein Localization
Membrane Organization
Activation Of GTPase Activity
Regulation Of Cilium Assembly
Regulation Of Heart Rate
Detection Of Calcium Ion
G Protein-coupled Receptor Signaling Pathway
Positive Regulation Of Peptidyl-threonine Phosphorylation
Negative Regulation Of Peptidyl-threonine Phosphorylation
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Substantia Nigra Development
Positive Regulation Of Protein Autophosphorylation
Regulation Of Cytokinesis
Positive Regulation Of Phosphoprotein Phosphatase Activity
Positive Regulation Of Protein Dephosphorylation
Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Response To Calcium Ion
Regulation Of Cardiac Muscle Contraction
Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Positive Regulation Of Protein Serine/threonine Kinase Activity
Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
CaMK IV-mediated phosphorylation of CREB
CaMK IV-mediated phosphorylation of CREB
Calmodulin induced events
Cam-PDE 1 activation
CaM pathway
Platelet degranulation
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
PKA activation
DARPP-32 events
Synthesis of IP3 and IP4 in the cytosol
Calcineurin activates NFAT
Calcineurin activates NFAT
eNOS activation
Transcriptional activation of mitochondrial biogenesis
Inactivation, recovery and regulation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade
Stimuli-sensing channels
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
Ca2+ pathway
Reduction of cytosolic Ca++ levels
Sodium/Calcium exchangers
Unblocking of NMDA receptors, glutamate binding and activation
CREB1 phosphorylation through the activation of Adenylate Cyclase
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Ras activation upon Ca2+ influx through NMDA receptor
Smooth Muscle Contraction
Smooth Muscle Contraction
Activation of Ca-permeable Kainate Receptor
Uptake and function of anthrax toxins
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
Phase 0 - rapid depolarisation
Ion homeostasis
CLEC7A (Dectin-1) induces NFAT activation
CLEC7A (Dectin-1) induces NFAT activation
RHO GTPases activate IQGAPs
RHO GTPases activate PAKs
RHO GTPases activate PAKs
RAF activation
RAF/MAP kinase cascade
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Glycogen breakdown (glycogenolysis)
Glycogen breakdown (glycogenolysis)
Protein methylation
Extra-nuclear estrogen signaling
Loss of phosphorylation of MECP2 at T308
Regulation of MECP2 expression and activity
Ion transport by P-type ATPases
Negative regulation of NMDA receptor-mediated neuronal transmission
Activation of RAC1 downstream of NMDARs
Activation of RAC1 downstream of NMDARs
Activation of AMPK downstream of NMDARs
Long-term potentiation
Long-term potentiation
RAS processing
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
FCGR3A-mediated IL10 synthesis
FCGR3A-mediated IL10 synthesis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Chlorpromazine
Cinchocaine
Nicardipine
Fluphenazine
Isoflurane
Trifluoperazine
Loperamide
Perphenazine
Phenoxybenzamine
Felodipine
Melatonin
Promethazine
Pimozide
Nifedipine
Bepridil
Calcium
Aprindine
Deacetoxyvinzolidine
tert-butanol
Trimethyllysine
N-(6-Aminohexyl)-5-Chloro-1-Naphthalenesulfonamide
Prenylamine
Flunarizine
(3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE
Myristic acid
Calcium citrate
Calcium citrate
Calcium citrate
Calcium Phosphate
Calcium Phosphate
Calcium Phosphate
Calcium levulinate
Calcium phosphate dihydrate
Calcium phosphate dihydrate
Calcium phosphate dihydrate
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals (
22959728
)
Crohn's disease (
23850713
23266558
)
Diastolic blood pressure (
27841878
27618452
)
Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) (
33208821
)
Lymphocyte counts (
32888494
27863252
)
Lymphocyte percentage of white cells (
32888494
27863252
)
Monocyte count (
32888494
)
Monocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
27863252
)
Periodontal microbiota (
22699663
)
Pulse pressure (
27841878
)
Response to antidepressants (symptom remission) (
29160301
)
Response to SSRI (symptom remission) (
29160301
)
Systolic blood pressure (
27841878
27618452
)
Verbal declarative memory (
25648963
)
Weight (
28552196
)
White blood cell count (
32888494
)
Dialysis-related mortality (
21546767
)
Interacting Genes
31 interacting genes:
CALM1
CALM2
CALM3
CCDC185
CWF19L2
EFHC2
FAM161A
FAM50B
GABARAPL1
GMCL1
HOXC8
HSF2BP
HSPB1
KRT75
L3MBTL3
LHX8
LNX1
LZTS1
MAP1LC3A
MCRS1
PNKP
RIN1
SMAD2
SYTL4
TCEA2
TNNC2
TSGA10IP
TXLNA
VPS52
YWHAG
ZFP1
52 interacting genes:
ADAMTS12
ADCY8
AKAP9
ASCL2
C11orf65
CACNA1A
CALD1
CAMTA2
CCND2
DDIT4L
DLG1
EDF1
EGFR
ESR1
ESR2
GRM5
GRM7
GSC2
INSR
INVS
IQCB1
IQCE
IQCG
IQCN
IQGAP3
KCNIP3
KCNN1
KCNQ2
KCNQ3
KCNQ5
MARCKS
MRPL20
MYF5
MYF6
MYO6
MYOD1
MYOG
NEUROD1
NSMF
PCNT
POC5
PPEF1
PPEF2
RAB3B
RPSA
SDCBP
SPATA17
STK11
TBC1D1
TCF4
USP6
ZNF280A
Entrez ID
23216
805
HPRD ID
18161
00242
Ensembl ID
ENSG00000065882
ENSG00000143933
Uniprot IDs
B9A6J6
Q6PJJ8
Q86TI0
Q8NC59
B4DJ51
P0DP23
P0DP24
P0DP25
Q96HY3
PDB IDs
3QYE
1AJI
1CDL
1CLL
1CTR
1IWQ
1J7O
1J7P
1K90
1K93
1L7Z
1LVC
1NKF
1PK0
1S26
1SK6
1SW8
1UP5
1WRZ
1XFU
1XFV
1XFW
1XFX
1XFY
1XFZ
1Y6W
1YR5
1YRT
1YRU
1ZOT
1ZUZ
2BE6
2F3Y
2F3Z
2HF5
2I08
2JZI
2K0E
2K0F
2K0J
2K61
2KNE
2KUG
2KUH
2L53
2L7L
2LGF
2LL6
2LL7
2LQC
2LQP
2LV6
2M0J
2M0K
2M55
2MG5
2N27
2N6A
2N77
2N8J
2R28
2V01
2V02
2VAY
2W73
2WEL
2X0G
2Y4V
3BYA
3DVE
3DVJ
3DVK
3DVM
3EWT
3EWV
3G43
3HR4
3J41
3O77
3O78
3OXQ
3SUI
3UCT
3UCW
3UCY
4BW7
4BW8
4BYF
4DCK
4DJC
4GOW
4JPZ
4JQ0
4L79
4LZX
4M1L
4OVN
4Q57
4Q5U
4UMO
4UPU
4V0C
5COC
5DBR
5DOW
5DSU
5GGM
5I0I
5J03
5J8H
5JQA
5JTH
5K7L
5K8Q
5NIN
5OEO
5TP5
5TP6
5V02
5V03
5V7X
5VMS
5WBX
5WC5
5WSU
5WSV
6B8L
6B8M
6B8N
6B8P
6B8Q
6BUT
6C1D
6C1G
6C1H
6CNM
6CNN
6CNO
6DAD
6DAE
6DAF
6DAH
6E2F
6E2G
6EEB
6FEG
6FEH
6GDK
6GDL
6HCS
6HR1
6JI8
6JII
6JIU
6JIY
6JRS
6JV2
6K4K
6K4L
6K4R
6K67
6M2W
6M7H
6MUD
6MUE
6N5W
6O5G
6OS4
6PAW
6PBX
6PBY
6PLM
6S5T
6SZ5
6U39
6U3A
6U3B
6U3D
6UZZ
6V00
6V01
6Y4O
6Y4P
6Y94
6Y95
7CR3
7CR4
7CR7
Enriched GO Terms of Interacting Partners
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