TBC1D1 and SMAD2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TBC1D1	SMAD2
Description		TBC1 domain family member 1	SMAD family member 2
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GO Annotations	Cellular Component	Nucleus Cytosol	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Activin Responsive Factor Complex Protein-containing Complex SMAD Protein Complex Heteromeric SMAD Protein Complex
	Molecular Function	GTPase Activator Activity Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Transcription Factor Binding Phosphatase Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding Type I Transforming Growth Factor Beta Receptor Binding SMAD Binding Metal Ion Binding Tau Protein Binding Co-SMAD Binding I-SMAD Binding R-SMAD Binding Disordered Domain Specific Binding
	Biological Process	Intracellular Protein Transport Regulation Of Protein Localization Membrane Organization Activation Of GTPase Activity Regulation Of Cilium Assembly	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development In Utero Embryonic Development Endoderm Formation Mesoderm Formation Regulation Of Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation SMAD Protein Complex Assembly Zygotic Specification Of Dorsal/ventral Axis Gastrulation Negative Regulation Of Cell Population Proliferation Anatomical Structure Morphogenesis Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Protein Deubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Insulin Secretion Cell Differentiation Lung Development Adrenal Gland Development BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of BMP Signaling Pathway Pancreas Development Primary MiRNA Processing Activin Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Organ Growth Intracellular Signal Transduction Nodal Signaling Pathway Wound Healing Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Morphogenesis Embryonic Foregut Morphogenesis Embryonic Cranial Skeleton Morphogenesis Regulation Of Binding Pericardium Development SMAD Protein Signal Transduction Secondary Palate Development Response To Cholesterol Positive Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane	Signaling by NODAL Signaling by NODAL Signaling by Activin Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/3 Phosphorylation Motif Mutants in Cancer SMAD4 MH2 Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer Transcriptional regulation of pluripotent stem cells Ub-specific processing proteases FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes
Drugs			Dexfosfoserine
Diseases			Colorectal cancer
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals ( 22959728) Crohn's disease ( 23850713 23266558) Diastolic blood pressure ( 27841878 27618452) Gut microbiota relative abundance (unclassified genus belonging to family Lachnospiraceae) ( 33208821) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252) Periodontal microbiota ( 22699663) Pulse pressure ( 27841878) Response to antidepressants (symptom remission) ( 29160301) Response to SSRI (symptom remission) ( 29160301) Systolic blood pressure ( 27841878 27618452) Verbal declarative memory ( 25648963) Weight ( 28552196) White blood cell count ( 32888494)	Coronary artery disease in type 1 diabetes ( 29695241) Lung cancer in ever smokers ( 28604730) Menarche (age at onset) ( 27182965)
Interacting Genes		31 interacting genes: CALM1 CALM2 CALM3 CCDC185 CWF19L2 EFHC2 FAM161A FAM50B GABARAPL1 GMCL1 HOXC8 HSF2BP HSPB1 KRT75 L3MBTL3 LHX8 LNX1 LZTS1 MAP1LC3A MCRS1 PNKP RIN1 SMAD2 SYTL4 TCEA2 TNNC2 TSGA10IP TXLNA VPS52 YWHAG ZFP1	219 interacting genes: ABTB1 ACVR1B AFDN AKT1 ANAPC10 ANAPC2 ANK3 ANP32B ANP32E ANTXR2 AP1B1 ARFGAP3 ARHGEF6 ARL4D ATP5ME AXIN1 BAZ1A BECN1 BPTF BRCA1 BTBD2 C22orf46 CAMK2A CAMK2G CDC16 CDC27 CDC40 CDK2 CDK4 CDK8 CDK9 CISH COPS5 CORO2A CREBBP CSH1 CSH2 CSNK1D CTNNB1 CUL5 CYLC2 CYP11A1 DAB2 DCAF6 DCUN1D1 DENND2B DNAJB5 DNAJC7 DOCK8 DVL1 DYNC1H1 E2F4 EEF1A1 EID2 EIF3L ELAC2 EP300 ERBIN ESR1 ESR2 FAM161B FBN2 FBP2 FHL2 FHL3 FOXG1 FOXH1 FOXO3 GATAD2B GFER GLI3 GRIPAP1 GSC GTF2I HDAC1 HDAC2 HGS HIPK2 HNF4A HOXA13 HOXA9 HOXD13 HSD17B3 HUWE1 HYAL2 INSR IRAK2 ITCH JUN KAT2B KHDRBS1 KPNB1 LAMA5 LATS2 LCK LEF1 LEMD3 LHX9 LITAF LMO2 MAP2K1 MAPK1 MAPK3 MAPK8 MAPK9 MECOM MED15 MED6 MEF2A MEF2C MYC MYOCD NAGK NCOA6 NEDD4L NEDD9 NEFM NFIA NFYC NOTCH4 NUAK2 NUP153 NUP214 OS9 OTUB1 PAK1 PAPOLA PAPPA PARD3 PAXIP1 PEX19 PIAS3 PIAS4 PIK3CA PLIN3 POU2AF1 PPM1A PPP2R1A PRKAR1A PSAP PSG9 PSMD11 PSMD8 PTMS RAB34 RAB38 RAN RANBP6 RANBP9 RARB RASA1 RASD2 RASL12 RBL1 RHEBL1 RHOA RHOD RHOJ RIT1 RNF123 RNPC3 ROCK1 RPS14 RPS27A RUNX2 RXRA SKI SKIL SKOR2 SMAD1 SMAD3 SMAD4 SMAD7 SMAD9 SMURF1 SMURF2 SNAPIN SNIP1 SNRNP70 SNW1 SOD1 SP1 SQSTM1 SRI ST13 STAG1 STAMBP STAMBPL1 STRAP STUB1 SYT1 TBC1D1 TGFBR1 TGFBRAP1 TGIF1 TGM2 TNNT1 TOB1 TP53 TP73 TRIM62 TRMO TSC2 TUBA1B UBA52 UBR5 UCHL5 USP9X WASHC4 XPA YY1 ZEB1 ZEB2 ZFYVE9 ZMYND11 ZNF41 ZNF510 ZNF8 ZNHIT6
Entrez ID		23216	4087
HPRD ID		18161	03221
Ensembl ID		ENSG00000065882	ENSG00000175387
Uniprot IDs		B9A6J6 Q6PJJ8 Q86TI0 Q8NC59	B7Z5N5 Q15796 Q53XR6
PDB IDs		3QYE	1DEV 1KHX 1U7V 2LB3 5XOD 5ZOJ 6H3R
Enriched GO Terms of Interacting Partners?
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